• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

氟轻松玻璃体内植入物治疗 Vogt-小柳原田病。

Fluocinolone acetonide intravitreal implants in Vogt-Koyanagi-Harada disease.

机构信息

F.I. Proctor Foundation, University of California, San Francisco, California 94143-0412, USA.

出版信息

Ocul Immunol Inflamm. 2009 Nov-Dec;17(6):431-3. doi: 10.3109/09273940903267936.

DOI:10.3109/09273940903267936
PMID:20001265
Abstract

PURPOSE

To describe the use of fluocinolone acetonide implants (Retisert) in Vogt-Koyanagi-Harada disease (VKH).

DESIGN

Interventional case series.

METHODS

Retrospective review of medical records.

RESULTS

Two patients with VKH requiring high-dose systemic corticosteroid therapy to control their inflammation and bilateral serous retinal detachments received bilateral fluocinolone acetonide implants. Upon tapering of systemic corticosteroids, one patient had recurrent serous retinal detachments and the other patient's anterior chamber and vitreous inflammation returned.

CONCLUSIONS

The authors' experience with fluocinolone acetonide implants in VKH has been mixed with an inability to fully taper off of systemic corticosteroids.

摘要

目的

描述在 Vogt-小柳-原田病(VKH)中使用氟轻松醋酸酯植入物(Retisert)的情况。

设计

介入性病例系列研究。

方法

回顾性病历审查。

结果

两名 VKH 患者需要大剂量全身皮质类固醇治疗来控制炎症和双侧浆液性视网膜脱离,他们接受了双侧氟轻松醋酸酯植入物治疗。在逐渐减少全身皮质类固醇治疗剂量后,一名患者出现复发性浆液性视网膜脱离,另一名患者的前房和玻璃体炎症复发。

结论

作者在 VKH 中使用氟轻松醋酸酯植入物的经验喜忧参半,无法完全停用全身皮质类固醇。

相似文献

1
Fluocinolone acetonide intravitreal implants in Vogt-Koyanagi-Harada disease.氟轻松玻璃体内植入物治疗 Vogt-小柳原田病。
Ocul Immunol Inflamm. 2009 Nov-Dec;17(6):431-3. doi: 10.3109/09273940903267936.
2
Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt-Koyanagi-Harada syndrome.玻璃体内注射曲安奈德治疗Vogt-小柳-原田综合征的浆液性视网膜脱离
Am J Ophthalmol. 2004 Mar;137(3):572-4. doi: 10.1016/j.ajo.2003.08.035.
3
FLUOCINOLONE ACETONIDE IMPLANT FOR VOGT-KOYANAGI-HARADA DISEASE: Three-Year Outcomes of Efficacy and Safety.用于伏格特-小柳-原田病的醋酸氟轻松植入剂:三年疗效与安全性结果
Retina. 2016 Nov;36(11):2124-2131. doi: 10.1097/IAE.0000000000001094.
4
Elevated choroidal blood flow velocity during systemic corticosteroid therapy in Vogt-Koyanagi-Harada disease.伏格特-小柳-原田病全身应用皮质类固醇治疗期间脉络膜血流速度升高
Acta Ophthalmol. 2008 Dec;86(8):902-7. doi: 10.1111/j.1755-3768.2008.01384.x. Epub 2008 Nov 12.
5
Effects of the duration of initial oral corticosteroid treatment on the recurrence of inflammation in Vogt-Koyanagi-Harada disease.初始口服皮质类固醇治疗持续时间对 Vogt-小柳原田病炎症复发的影响。
Eye (Lond). 2009 Mar;23(3):543-8. doi: 10.1038/eye.2008.89. Epub 2008 Mar 28.
6
Evaluation of an intravitreal fluocinolone acetonide implant versus standard systemic therapy in noninfectious posterior uveitis.评价玻璃体内注射氟轻松醋酸酯植入剂与标准全身治疗在非感染性后部葡萄膜炎中的效果。
Ophthalmology. 2010 Mar;117(3):567-75, 575.e1. doi: 10.1016/j.ophtha.2009.11.027. Epub 2010 Jan 15.
7
Long-term follow-up results of a pilot trial of a fluocinolone acetonide implant to treat posterior uveitis.醋酸氟轻松植入剂治疗后葡萄膜炎的一项试点试验的长期随访结果
Ophthalmology. 2005 Jul;112(7):1192-8. doi: 10.1016/j.ophtha.2005.03.013.
8
Management of sympathetic ophthalmia with the fluocinolone acetonide implant.曲安奈德植入物治疗交感性眼炎
Ophthalmology. 2009 Mar;116(3):552-557.e1. doi: 10.1016/j.ophtha.2008.10.024. Epub 2009 Jan 14.
9
Evaluation of the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease.评估急性Vogt-小柳-原田病中糖皮质激素给药途径对预后的影响。
Am J Ophthalmol. 2006 Jul;142(1):119-24. doi: 10.1016/j.ajo.2006.02.049.
10
Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease.伏格特-小柳-原田病前段复发时并发脉络膜炎症。
Am J Ophthalmol. 2008 Mar;145(3):480-486. doi: 10.1016/j.ajo.2007.10.012. Epub 2008 Jan 11.

引用本文的文献

1
Long-term efficacy of dexamethasone intravitreal implant in the treatment of Vogt-Koyanagi-Harada disease relapsing posterior uveitis.地塞米松玻璃体内植入剂治疗 Vogt-小柳原田病复发后葡萄膜炎的长期疗效。
Indian J Ophthalmol. 2022 Jul;70(7):2465-2470. doi: 10.4103/ijo.IJO_260_22.
2
Intravitreal methotrexate and fluocinolone acetonide implantation for Vogt-Koyanagi-Harada uveitis.玻璃体内注射甲氨蝶呤和氟轻松丙酮化物植入术治疗伏格特-小柳-原田葡萄膜炎
Am J Ophthalmol Case Rep. 2020 Aug 2;19:100859. doi: 10.1016/j.ajoc.2020.100859. eCollection 2020 Sep.
3
Reappraisal of the management of Vogt-Koyanagi-Harada disease: sunset glow fundus is no more a fatality.
Vogt-小柳-原田病管理的重新评估:晚霞样眼底不再是致命的表现。
Int Ophthalmol. 2017 Dec;37(6):1383-1395. doi: 10.1007/s10792-016-0395-0. Epub 2016 Nov 14.
4
Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes.伏格特-小柳-原田病:一种罕见的针对黑素细胞抗原的自身免疫性疾病的综述
Orphanet J Rare Dis. 2016 Mar 24;11:29. doi: 10.1186/s13023-016-0412-4.
5
Rituximab in refractory Vogt-Koyanagi-Harada disease.利妥昔单抗治疗难治性葡萄膜大脑炎
J Ophthalmic Inflamm Infect. 2011 Dec;1(4):177-80. doi: 10.1007/s12348-011-0027-9. Epub 2011 Jul 9.
6
Treatment of noninfectious posterior uveitis with dexamethasone intravitreal implant.地塞米松玻璃体内植入物治疗非感染性后葡萄膜炎
Clin Ophthalmol. 2010 Dec 6;4:1423-6. doi: 10.2147/OPTH.S15696.