Simpson Andrew C, McCown Jennifer L
Veterinary Medical Center, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
J Am Vet Med Assoc. 2009 Dec 15;235(12):1474-9. doi: 10.2460/javma.235.12.1474.
A 12-year-old 21.9-kg (48.48-lb) spayed female Alaskan Malamute with a long-term history of panting, polydypsia and polyuria, weight loss, hind limb weakness, and a decrease in appetite was evaluated for hypertension.
Use of Doppler sphygmomanometry revealed a systolic blood pressure of 250 mm Hg (mean value for 5 consecutive measurements). Palpation of the ventral cervical region revealed a fixed asymmetric mass in the area of the lobes of the thyroid gland. The portion of the mass on the right side was approximately 2 x 2 cm, whereas the portion of the mass on the left side was approximately 1 x 1.5 cm. Hyperthyroidism was diagnosed on the basis of high serum thyroxine concentrations. Thyroidectomy of both lobes of the gland was performed. Histologic examination revealed a bilateral, multilobulated, and encapsulated thyroid gland adenocarcinoma.
Thyroidectomy of both lobes of the gland was performed with clinical resolution of hypertension. The dog was treated postoperatively with chemotherapeutics, including doxorubicin and carboplatin, and external beam radiation. Calcium and thyroxine homeostasis fluctuated; however, the dog finally achieved concentrations within the respective reference ranges through the administration of calcitriol, calcium carbonate, and levothyroxine.
This report describes concurrent hypertension in a dog with a functional thyroid gland adenocarcinoma with subsequent return of blood pressure values to within reference ranges after thyroidectomy.
一只12岁、体重21.9千克（48.48磅）的已绝育雌性阿拉斯加雪橇犬，有长期气喘、烦渴、多尿、体重减轻、后肢无力及食欲减退的病史，因高血压接受评估。
使用多普勒血压计测量显示收缩压为250毫米汞柱（连续5次测量的平均值）。触诊颈腹侧区域发现甲状腺叶区域有一个固定的不对称肿块。右侧肿块部分约为2×2厘米，而左侧肿块部分约为1×1.5厘米。根据高血清甲状腺素浓度诊断为甲状腺功能亢进。对双侧甲状腺叶进行了甲状腺切除术。组织学检查显示为双侧、多叶、有包膜的甲状腺腺癌。
对双侧甲状腺叶进行了甲状腺切除术，高血压症状临床缓解。术后该犬接受了包括阿霉素和卡铂在内的化疗药物及外照射治疗。钙和甲状腺素稳态出现波动；然而，通过给予骨化三醇、碳酸钙和左甲状腺素，该犬最终实现了各指标在相应参考范围内的浓度。
本报告描述了一只患有功能性甲状腺腺癌的犬并发高血压，甲状腺切除术后血压值恢复至参考范围内。
