Langness U, Humke G, Tillman K
Wien Klin Wochenschr. 1977 Nov 11;89(21):720-3.
An investigation was carried out in 120 patients with classical rheumatoid arthritis (RA). Prolylhydroxylase activity was determined in the synovial membrane and serum and compared with the level of collagen-like protein in plasma and the hydroxyproline-creatinine quotient in urine. The data were related to the activity of RA as measured according to Voit and Gamp and also according to Lansbury. Activity was, furthermore, also assessed on the basis of newly defined criteria considering clinical, biochemical and histological findings. Prolylhydroxylase activity was significantly correlated to the activity of the RA assessed according to each of these systems. The significance of the known parameters, collagen-like protein in plasma and hydroxyproline-creatinine quotient in urine were confirmed in this larger series of patients. The positive correlation between prolylhydroxylase activities in the synovial membrane, as well as in serum, and the level of collagen metabolites in plasma and urine corroborated the value of biochemical methods in the assessment of activity of RA in order to undertake differentiated therapy.
对120例典型类风湿性关节炎（RA）患者进行了一项调查。测定了滑膜和血清中的脯氨酰羟化酶活性，并与血浆中胶原样蛋白水平及尿中羟脯氨酸 - 肌酐商进行比较。这些数据与根据沃特（Voit）和甘普（Gamp）以及兰斯伯里（Lansbury）方法测定的RA活动度相关。此外，还根据考虑临床、生化和组织学结果的新定义标准对活动度进行了评估。脯氨酰羟化酶活性与根据这些系统中的每一个所评估的RA活动度显著相关。在这一更大系列的患者中证实了已知参数血浆中胶原样蛋白和尿中羟脯氨酸 - 肌酐商的意义。滑膜以及血清中脯氨酰羟化酶活性与血浆和尿液中胶原代谢产物水平之间的正相关证实了生化方法在评估RA活动度以进行个体化治疗方面的价值。
