胃泌素-17及甘氨酸胃泌素-17在胃肠道癌症中的产生及作用
The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.
作者信息
Copps Jeffrey, Murphy Richard F, Lovas Sándor
机构信息
Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
出版信息
Protein Pept Lett. 2009;16(12):1504-18. doi: 10.2174/092986609789839269.
The gastrointestinal peptide hormone gastrin is responsible for initiating the release of gastric acid in the stomach in response to the presence of food and/or humoral factors such as gastrin releasing peptide. However, it has a role in the growth and maintenance of the gastric epithelium, and has been implicated in the formation and growth of gastric cancers. Hypergastrinemia resulting from atrophic gastritis and pernicious anemia leads to hyperplasia and carcinoid formation in rats, and contributes to tumor formation in humans. Additionally, gastrin has been suspected to play a role in the formation and growth of cancers of the colon, but recent studies have instead implicated gastrin processing intermediates, such as gastrin-17-Gly, acting upon a putative, non-cholecystokinin receptor. This review summarizes the production and chemical structures of gastrin and of the processing intermediate gastrin-17-Gly, as well as their activities in the gastrointestinal tract, particularly the promotion of colon cancers.
胃肠肽激素胃泌素负责在胃中响应食物的存在和/或体液因子（如胃泌素释放肽）而启动胃酸的释放。然而，它在胃上皮细胞的生长和维持中发挥作用，并与胃癌的形成和生长有关。萎缩性胃炎和恶性贫血导致的高胃泌素血症会导致大鼠增生和类癌形成，并促进人类肿瘤形成。此外，胃泌素被怀疑在结肠癌的形成和生长中起作用，但最近的研究表明，胃泌素加工中间体，如胃泌素-17-甘氨酸，作用于一种假定的非胆囊收缩素受体。本综述总结了胃泌素和加工中间体胃泌素-17-甘氨酸的产生、化学结构及其在胃肠道中的活性，特别是对结肠癌的促进作用。
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