Department of Physiology in Zabrze, Medical University of Silesia, Katowice, Poland.
J Viral Hepat. 2010 Sep;17(9):661-7. doi: 10.1111/j.1365-2893.2009.01224.x. Epub 2009 Nov 11.
Adipocytokine profile seems to play a distinct role in the pathogenesis of chronic hepatitis C (CHC). Chemerin and vaspin are recently described adipocytokines with various suggested functions and potential to modulate inflammatory response and insulin resistance (IR). We assessed chemerin, vaspin and leptin serum concentration and studied their association with IR laboratory and morphological features in patients with hepatitis C. The study included 40 patients with hepatitis C and 20 healthy volunteers, similar in age and body mass index (43.6 +/- 11.6 vs 40.9 +/- 11.8 years and 25.0 +/- 4.1 vs 23.9 +/- 3.3 kg/m(2), respectively). Patients had to have a normal lipid profile, and diabetes was an exclusion criteria. Serum chemerin and leptin levels and IR were significantly higher in patients with hepatitis C when compared to the controls (P = 0.02, P = 0.02 and P = 0.02, respectively), whereas vaspin level was significantly decreased (P = 0.01). Serum chemerin was negatively associated with necro-inflammatory grade (r = (-0.49), P = 0.01). The lowest levels of serum chemerin were found in patients with moderate/severe inflammation (P = 0.03). Serum leptin tended to be up-regulated in patients with minimal inflammatory activity. Serum vaspin was higher, although not significantly, when fibrosis was more advanced. IR was positively associated with fibrosis stage (r = 0.33, P = 0.03). Serum chemerin and leptin were related to each other (r = 0.45, P = 0.02).Our findings support a complex interaction between the analysed adipokines and pathogenesis of inflammatory process in CHC. The role of chemerin and vaspin in pathogenesis of inflammatory response should be further investigated.
脂肪细胞因子谱似乎在慢性丙型肝炎 (CHC) 的发病机制中发挥独特作用。Chemerin 和 vaspin 是最近描述的脂肪细胞因子，具有各种功能，并具有调节炎症反应和胰岛素抵抗 (IR) 的潜力。我们评估了 Chemerin、vaspin 和瘦素的血清浓度，并研究了它们与丙型肝炎患者的 IR 实验室和形态学特征的关系。该研究包括 40 例丙型肝炎患者和 20 名健康志愿者，年龄和体重指数 (43.6 +/- 11.6 岁与 40.9 +/- 11.8 岁和 25.0 +/- 4.1 公斤/平方米与 23.9 +/- 3.3 公斤/平方米) 相似。患者的血脂谱必须正常，且糖尿病为排除标准。与对照组相比，丙型肝炎患者的血清 Chemerin 和瘦素水平及 IR 显著升高 (P = 0.02、P = 0.02 和 P = 0.02)，而 vaspin 水平显著降低 (P = 0.01)。血清 Chemerin 与坏死性炎症程度呈负相关 (r = (-0.49)，P = 0.01)。中度/重度炎症患者的血清 Chemerin 水平最低 (P = 0.03)。血清瘦素在炎症活动最低的患者中呈上调趋势。虽然不显著，但纤维化程度较高时，血清 vaspin 较高。IR 与纤维化分期呈正相关 (r = 0.33，P = 0.03)。血清 Chemerin 和瘦素相互关联 (r = 0.45，P = 0.02)。我们的发现支持分析的脂肪细胞因子与 CHC 炎症过程发病机制之间的复杂相互作用。Chemerin 和 vaspin 在炎症反应发病机制中的作用需要进一步研究。
