Kukla Michał, Berdowska Agnieszka, Gabriel Andrzej, Sawczyn Tomasz, Mazur Włodzimierz, Sobala-Szczygieł Barbara, Grzonka Dariusz, Zajęcki Wojciech, Tomaszek Krzysztof, Bułdak Rafał J, Zwirska-Korczala Krystyna
Department of Physiology, Medical University of Silesia, Katowice, Poland.
Pol J Pathol. 2011 Dec;62(4):218-28.
It is unclear whether angiogenesis merely represents a homeostatic mechanism aimed at ensuring an adequate oxygen supply or one that exerts an additional pathogenic role leading to liver damage in chronic hepatitis. Chronic hepatitis C (CHC) patients present a proangiogenic profile of angiogenic markers. Adipokines not only regulate adipose tissue and glucose metabolism, but also influence inflammation, fibrogenic process and production of proangiogenic factors. On the basis of this evidence we aimed to assess the number of new blood vessels in lobules and portal tracts in the liver and evaluate the relationship between angiogenesis intensity and serum adipokine concentrations in CHC. Our study showed a positive association between serum vaspin and angiogenesis intensity in portal tracts and lobules in CHC patients (r = 0.41, p = 0.04; r = 0.46, p = 0.03; respectively). Serum visfatin was found to be negatively related to angiogenesis in portal tracts and lobules but only in females (r = -0.76, p = 0.03; r= -0.95, p < 0.001; respectively). In conclusion, the role of some adipokines in liver angiogenesis seems to be different in females than in males. Serum vaspin concentration seems to reflect intensity of liver angiogenesis in CHC. Further studies are necessary to better determine the role of adipokines in new blood vessel formation in CHC.
目前尚不清楚血管生成仅仅是一种旨在确保充足氧气供应的稳态机制，还是一种在慢性肝炎中发挥额外致病作用导致肝损伤的机制。慢性丙型肝炎（CHC）患者呈现出血管生成标志物的促血管生成特征。脂肪因子不仅调节脂肪组织和葡萄糖代谢，还影响炎症、纤维化过程以及促血管生成因子的产生。基于这一证据，我们旨在评估肝小叶和门管区新血管的数量，并评估CHC中血管生成强度与血清脂肪因子浓度之间的关系。我们的研究表明，CHC患者血清内脂素与门管区和肝小叶的血管生成强度呈正相关（分别为r = 0.41，p = 0.04；r = 0.46，p = 0.03）。发现血清内脏脂肪素仅在女性中与门管区和肝小叶的血管生成呈负相关（分别为r = -0.76，p = 0.03；r = -0.95，p < 0.001）。总之，某些脂肪因子在肝脏血管生成中的作用在女性和男性中似乎有所不同。血清内脂素浓度似乎反映了CHC中肝脏血管生成的强度。需要进一步研究以更好地确定脂肪因子在CHC新血管形成中的作用。
