Department of Orbital, Oculoplastic and Reconstructive Surgery, Duke Eye Center, Durham, North Carolina, USA.
Dermatol Surg. 2010;36(1):109-12. doi: 10.1111/j.1524-4725.2009.01391.x. Epub 2009 Dec 4.
Patients often complain of pain and bruising from needle injections. Some clinicians believe smaller gauge needles cause less pain. Thirty-gauge needles are currently the standard needles employed for administering botulinum toxin type A (BTX-A).
This study sought to determine whether patients receiving BTX-A have a preference for 30-gauge or 32-gauge needles based on the amount of pain and bruising experienced.
Thirty-seven subjects received BTX-A on the right side of the face using a 30-gauge needle and on the left side using a 32-gauge needle. Subjects were masked to needle size. They were then asked to rate injection pain on an 11-point numerical rating scale and to note any bruising. Physician preference was also evaluated.
There were no statistically significant differences in the amount of intra-procedural pain (p=.37) or the level of post-procedural pain and discomfort (p=.76) experienced. Twenty-seven percent of subjects reported greater bruising with the 32-gauge needle, versus 29.7% with the 30-gauge needle. The physician injector did not have a preference. Lastly, 83.8% of subjects did not detect a difference in BTX-A paralysis effect.
We do not recommend using 32-gauge needles in place of 30-gauge needles for administering BTX-A.
患者经常抱怨针注射引起的疼痛和瘀伤。一些临床医生认为，较小规格的针头造成的疼痛较小。目前，30 号针头是用于注射肉毒毒素 A（BTX-A）的标准针头。
本研究旨在确定患者在接受 BTX-A 治疗时，是否会根据疼痛和瘀伤的程度，对 30 号和 32 号针头有偏好。
37 名受试者的右侧面部使用 30 号针头，左侧使用 32 号针头接受 BTX-A 注射。受试者对针头规格进行了盲法处理。然后，他们被要求使用 11 分数字评分量表来评估注射疼痛，并记录任何瘀伤。还评估了医生的偏好。
术中疼痛程度（p=.37）或术后疼痛和不适程度（p=.76）无统计学差异。27%的受试者报告使用 32 号针头时瘀伤更严重，而使用 30 号针头时瘀伤比例为 29.7%。医生注射者没有偏好。最后，83.8%的受试者未检测到 BTX-A 麻痹效果的差异。
我们不建议用 32 号针头代替 30 号针头来注射 BTX-A。
