Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
Allergy. 2010 Jul;65(7):903-10. doi: 10.1111/j.1398-9995.2009.02284.x. Epub 2009 Dec 11.
Itch is a major symptom of allergic skin disease. Acupuncture has been shown to exhibit a significant effect on histamine-induced itch in healthy volunteers. We investigated the effect of acupuncture on type I hypersensitivity itch and skin reaction in a double-blind, randomized, placebo-controlled, crossover trial.
An allergen stimulus (house dust mite or grass pollen skin prick) was applied to 30 patients with atopic eczema before (direct effect) and after (preventive effect) two experimental approaches or control observation: acupuncture at points Quchi and Xuehai [verum acupuncture (VA), dominant side], 'placebo-point' acupuncture (PA, dominant side), no acupuncture (NA). Itch intensity was recorded on a visual analogue scale. After 10 min, wheal and flare size and skin perfusion (via LASER-Doppler) were measured at the stimulus site, and the validated Eppendorf Itch Questionnaire (EIQ) was answered.
Mean itch intensity was significantly lower in VA (35.7 +/- 6.4) compared to NA (45.9 +/- 7.8) and PA (40.4 +/- 5.8) regarding the direct effect; and significantly lower in VA (34.3 +/- 7.1) and PA (37.8 +/- 5.6) compared to NA (44.6 +/- 6.2) regarding the preventive effect. In the preventive approach, mean wheal and flare size were significantly smaller in VA (0.38 +/- 0.12 cm(2)/8.1 +/- 2.0 cm(2)) compared to PA (0.54 +/- 0.13 cm(2)/13.5 +/- 2.8 cm(2)) and NA (0.73 +/- 0.28 cm(2)/15.1 +/- 4.1 cm(2)), and mean perfusion in VA (72.4 +/- 10.7) compared to NA (84.1 +/- 10.7). Mean EIQ ratings were significantly lower in VA compared to NA and PA in the treatment approach; and significantly lower in VA and PA compared to NA in the preventive approach.
Acupuncture at the correct points showed a significant reduction in type I hypersensitivity itch in patients with atopic eczema. With time the preventive point-specific effect diminished with regard to subjective itch sensation, whereas it increased in suppressing skin-prick reactions.
瘙痒是过敏性皮肤病的主要症状。针刺已被证明对健康志愿者的组胺诱导瘙痒具有显著疗效。我们在一项双盲、随机、安慰剂对照、交叉试验中研究了针刺对 I 型超敏反应性瘙痒和皮肤反应的影响。
在 30 例特应性皮炎患者接受变应原刺激（屋尘螨或草花粉皮肤点刺）之前（直接效应）和之后（预防效应），采用两种实验方法或对照观察：曲池和血海穴针刺（真针刺（VA），优势侧）、“假针刺”（PA，优势侧）、不针刺（NA）。瘙痒强度采用视觉模拟评分法记录。10 分钟后，在刺激部位测量风团和红斑大小及皮肤灌注（通过激光多普勒），并回答经过验证的 Eppendorf 瘙痒问卷（EIQ）。
VA 组（35.7 ± 6.4）的平均瘙痒强度明显低于 NA 组（45.9 ± 7.8）和 PA 组（40.4 ± 5.8），VA 组（34.3 ± 7.1）和 PA 组（37.8 ± 5.6）的平均瘙痒强度明显低于 NA 组（44.6 ± 6.2），具有直接效应；VA 组（35.7 ± 6.4）和 PA 组（34.3 ± 7.1）的平均瘙痒强度明显低于 NA 组（44.6 ± 6.2），具有预防效应。在预防方法中，VA 组的平均风团和红斑大小（0.38 ± 0.12 cm2/8.1 ± 2.0 cm2）明显小于 PA 组（0.54 ± 0.13 cm2/13.5 ± 2.8 cm2）和 NA 组（0.73 ± 0.28 cm2/15.1 ± 4.1 cm2），VA 组的平均灌注（72.4 ± 10.7）明显小于 NA 组（84.1 ± 10.7）。VA 组在治疗方法中的平均 EIQ 评分明显低于 NA 组和 PA 组；VA 组和 PA 组在预防方法中的平均 EIQ 评分明显低于 NA 组。
针刺正确穴位可显著减轻特应性皮炎患者的 I 型超敏反应性瘙痒。随着时间的推移，预防穴位的特定效应在主观瘙痒感觉方面减弱，而在抑制皮肤点刺反应方面增强。
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