Department of Neurology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea.
Acta Neurol Scand. 2010 May;121(5):342-7. doi: 10.1111/j.1600-0404.2009.01222.x. Epub 2009 Dec 10.
Chronic inflammatory demyelinating polyradiculopathy (CIDP) is less well-studied in children than in adults, probably due to its relative rarity. This study was performed in order to characterize the clinical features of CIDP in children.
Twenty-eight patients with CIDP who were followed up for more than 1 year were included, and were divided into a child (n = 7, age <16) and an adult group (n = 21, age >or=16). Then, we have assessed the initial progression pattern, clinical course, and serial nerve conduction findings in each patient. Finally, differential features in child and adult group were analyzed.
Distinguishing features in the child group include subacute progression within less than 2 months, predominant motor system involvement in lower extremities, and marked improvement in response to immune modulating therapy. Our study also suggested that serial nerve conduction study may be useful in assessing the effectiveness of the treatment in children.
Our study showed that children with CIDP have some distinguishing features from adults in terms of clinical course and response to treatment.
儿童慢性炎症性脱髓鞘性多发性神经病（CIDP）的研究不如成人那么多，可能是因为其相对少见。本研究旨在描述儿童 CIDP 的临床特征。
我们纳入了 28 例随访超过 1 年的 CIDP 患者，将其分为儿童组（n = 7，年龄 <16 岁）和成年组（n = 21，年龄 >or=16 岁）。然后，我们评估了每位患者的初始进展模式、临床病程和连续神经传导研究结果。最后，对儿童组和成年组的差异特征进行了分析。
儿童组的特征包括在不到 2 个月内亚急性进展、下肢主要为运动系统受累，以及对免疫调节治疗有明显反应。我们的研究还表明，连续神经传导研究可能有助于评估儿童治疗的效果。
我们的研究表明，CIDP 患儿在临床病程和治疗反应方面与成人存在一些差异。
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