SOD2 T-9C 和 MTHFR C677T 多态性与长寿的关联：约旦人群的研究。
Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population.
机构信息
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
BMC Geriatr. 2009 Dec 15;9:57. doi: 10.1186/1471-2318-9-57.
BACKGROUND
Aging in animals is associated with high body oxidative stress, which might affect susceptibility and onset of age-related diseases, and the subsequent life span. Therefore, genes that modulate oxidative stress might play a role in determining longevity. In this study, we investigated whether the gene pool relevant to the SOD2-9T/C and MTHFR 677C/T polymorphisms changes as the Jordanian population ages.
METHODS
Polymorphisms were genotyped in 130 elderly subjects (57 females and 73 males, mean age: 90.01 years) and 135 young control subjects (67 females and 68 males, mean age: 33.43 years).
RESULTS
No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05).
CONCLUSION
SOD2-9T/C and MTHFR 677C/T gene polymorphisms do not seem to be important in Jordanian population for longevity phenotype.
背景
动物衰老与体内氧化应激水平高有关，而氧化应激可能会影响与年龄相关疾病的易感性和发病时间，以及随后的寿命。因此，调节氧化应激的基因可能在决定寿命方面发挥作用。在这项研究中，我们调查了与 SOD2-9T/C 和 MTHFR 677C/T 多态性相关的基因库是否会随着约旦人口的老龄化而发生变化。
方法
在 130 名老年受试者（57 名女性和 73 名男性，平均年龄：90.01 岁）和 135 名年轻对照组（67 名女性和 68 名男性，平均年龄：33.43 岁）中对多态性进行了基因分型。
结果
在老年组和年轻对照组之间（P>0.05），以及在分别考虑每个性别时（P>0.05），所检查的 SOD2 和 MTHFR 基因变体的基因型和等位基因频率均无显著差异。
结论
SOD2-9T/C 和 MTHFR 677C/T 基因多态性似乎不是约旦人群长寿表型的重要因素。
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