Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center/Academic Centre for Dentistry, Amsterdam, The Netherlands.
Oral Oncol. 2010 Jan;46(1):61-4. doi: 10.1016/j.oraloncology.2009.11.002. Epub 2009 Dec 9.
The 40-years of experience in a single institution with the treatment of previously untreated ameloblastoma have been reported, followed by a management protocol. Retrospectively, 25 consecutive patients treated between 1969 and 2009 have been analyzed. In 11 patients, a preoperative diagnosis of ameloblastoma was available. In the remaining 14 patients the diagnosis of ameloblastoma was a postoperative one. For the recurrence rate a minimum follow-up period of 5 years was observed; 20 patients met these criteria. After primary radical surgery in five patients, no recurrences were observed. In case of conservative surgical treatment, performed in 15 patients, a recurrence was observed in eight (53%) of them. Six of these patients were then treated successfully by radical surgery, while two patients refused such surgical approach. In one of the patients with a recurrence a cervical lymph node metastasis was detected at the same time, resulting in a diagnosis of metastasizing ameloblastoma.
本文报告了单一机构 40 年来治疗未经治疗的造釉细胞瘤的经验，并提出了治疗方案。回顾性分析了 1969 年至 2009 年间连续治疗的 25 例患者。11 例患者术前诊断为造釉细胞瘤，其余 14 例患者术后诊断为造釉细胞瘤。为了评估复发率，我们观察了至少 5 年的随访期；20 例患者符合这些标准。在 5 例患者中进行了初次根治性手术，无复发。在 15 例接受保守手术治疗的患者中，有 8 例（53%）复发。其中 6 例患者随后成功接受根治性手术治疗，而 2 例患者拒绝接受这种手术方法。在 1 例复发患者中，同时发现颈部淋巴结转移，诊断为转移性造釉细胞瘤。
