Department of Zoology, University of Pune, Pune, India.
Fitoterapia. 2010 Jul;81(5):403-12. doi: 10.1016/j.fitote.2009.11.011. Epub 2009 Dec 11.
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to either insufficiency of insulin or inability of cells to respond to insulin. Many clinical and experimental evidence have suggested the strong association between hyperglycemia, oxidative stress and diabetic complications. Therefore, the antidiabetic drugs with antioxidant potential would have a higher therapeutic value. To check its antidiabetic and antioxidant properties in vivo, experiments were done wherein mice were fed with Syndrex in different schedules and/or made diabetic by intraperitoneal injection of streptozotocin. Animals fed with Syndrex prior to the induction of diabetes by streptozotocin injection showed resistance to an increase in blood glucose levels. This treatment increased the activities of antioxidant enzymes namely, catalase, glutathione reductase and superoxide dismutase and reduced serum triglyceride and cholesterol levels as compared to those found in uncontrolled diabetic mice. Among the three different schedules used for Syndrex treatment, the best effect was seen in the case of mice pretreated with Syndrex prior to STZ injection. In our opinion, Syndrex given along with insulin may reduce the amount of insulin dose required and because of its strong antioxidant activity would certainly help to reduce the development of diabetic complications.
糖尿病是一种代谢紊乱，其特征是由于胰岛素不足或细胞对胰岛素无反应而导致的高血糖。许多临床和实验证据表明，高血糖、氧化应激和糖尿病并发症之间存在很强的关联。因此，具有抗氧化潜力的抗糖尿病药物将具有更高的治疗价值。为了在体内检查其抗糖尿病和抗氧化特性，进行了实验，其中用 Syndrex 以不同的方案喂养小鼠，或通过腹腔注射链脲佐菌素使它们患上糖尿病。在用链脲佐菌素注射诱导糖尿病之前用 Syndrex 喂养的动物表现出对血糖水平升高的抵抗力。与未控制的糖尿病小鼠相比，这种治疗方法增加了抗氧化酶的活性，如过氧化氢酶、谷胱甘肽还原酶和超氧化物歧化酶，并降低了血清甘油三酯和胆固醇水平。在用于 Syndrex 治疗的三种不同方案中，在预先用 Syndrex 预处理然后再注射 STZ 的小鼠中观察到最佳效果。在我们看来，与胰岛素一起给予 Syndrex 可能会减少所需胰岛素剂量，并且由于其强大的抗氧化活性，肯定有助于减少糖尿病并发症的发展。
