Center of Obstetrics and Gynecology, University Hospital of Frankfurt, D-60590 Frankfurt, Germany.
Contraception. 2010 Jan;81(1):57-61. doi: 10.1016/j.contraception.2009.07.011.
The effects of extended regimens of combined oral contraceptives (COC) on lipid parameters are largely unknown. The present study compared the effects of a COC containing 30 mcg ethinyl estradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year.
Lipid parameters were measured in 59 women treated with EE/DNG either conventionally (21+7 days) or in extended-cycle regimen (84+7 days). Blood samples were taken in a control cycle and at 3 and 12 months of treatment.
The mean levels of total cholesterol, HDL cholesterol and HDL(2) cholesterol underwent modest to moderate significant increases over time, while the significant increase in triglycerides and VLDL cholesterol was more pronounced with both regimens. LDL cholesterol decreased slightly in both regimen groups, whereas lipoprotein(a) was transiently decreased at 3 months only in the extended-cycle group. The changes reached a steady-state at latest at 3 months, but did not exceed the given normal ranges for any of the parameters. Notably, except for lipoprotein(a), the changes in mean lipid levels were not significantly different in the conventional and the extended-cycle regimen at 3 or 12 months of treatment.
Use of EE/DNG in conventional or extended-cycle regimen resulted in comparable changes of lipid parameters.
延长复方口服避孕药（COC）的疗程对血脂参数的影响尚不清楚。本研究比较了含 30 mcg 炔雌醇和 2 mg 地诺孕素的 COC 分别在常规和延长周期方案下治疗 1 年的效果。
59 名接受 EE/DNG 治疗的女性，分别采用常规方案（21+7 天）或延长周期方案（84+7 天），检测血脂参数。在对照周期和治疗 3 个月和 12 个月时采集血样。
总胆固醇、HDL 胆固醇和 HDL(2)胆固醇的平均水平随时间呈适度至中度显著增加，而两种方案的甘油三酯和 VLDL 胆固醇的显著增加更为明显。两种方案的 LDL 胆固醇均略有下降，而脂蛋白(a)仅在延长周期组中于 3 个月时短暂下降。这些变化最晚在 3 个月时达到稳定状态，但任何参数均未超过给定的正常范围。值得注意的是，除脂蛋白(a)外，在治疗 3 或 12 个月时，常规和延长周期方案的平均血脂水平变化无显著差异。
在常规或延长周期方案中使用 EE/DNG 可导致血脂参数的可比变化。
