Massoubre C, Bonnefond H, Grosselin A, Nelva A, Pellet J, Lang F
Service des urgences psychiatriques et unité de crise, hôpital Nord- bâtiment G, 42055 Saint-Etienne cedex 02, France.
Encephale. 2009 Dec;35(6):544-53. doi: 10.1016/j.encep.2008.09.007.
This work deals with the comparative study of two standardised instruments, which can be used to diagnose personality disorders (PD): the SCID-II and the DIP. Each instrument used as a self-questionnaire followed by a semi-structured interview by the same clinician was applied to 21 patients suffering from PD. The DIP (DSM-IV and ICD-10 Personality), which is a recent instrument, consists of a self-questionnaire (DIP-Q) and a semi-structured interview (DIP-I), created by Bodlund and Ottosson. It makes it possible to evaluate PD from criteria based on the DSM-IV as well as the ICD-10. We translated it into French then evaluated it in comparison with another instrument, the Structured Clinical Interview for DSM-IV Axis II PD (SCID-II) whose validity was demonstrated by Bouvard.
For the self-questionnaire (SCID-auto), we used CUNGI'S computerised version. The present version of the semi-structured interview SCID-E (French translation by Bouvard et al.) evaluates the 10 PD of the DSM-IV, the depressive personality and the passive-aggressive personality, included in the DSM-IV appendix B. The DIP-Q questionnaire is made up of 140 right/wrong items referring to the 10 PD of the DSM-IV and the eight disorders of the ICD-10. The DIP-I is the self-structured interview created by Ottosson et al. and it is built on the same pattern as the SCID-II. It provides diagnoses for all DSM-IV and/or ICD-10 PD as well as the schizotypic disorder. The DIP-I is usually preceded by a general "scan" interview in order to assess an existing personality disorder corresponding to Axis I of the DSM-IV or the ICD-10. In our study, we substituted a Mini International Neuropsychiatric Interview (MINI) questionnaire for this interview. Twenty-four patients suffering from one or several PD were chosen among ambulatory or out-patients by clinicians from the Saint-Etienne Psychiatric University Hospital Center. The diagnosis was not revealed to the examiner during the study. The subjects filled in the DIP-I and the SCID-II self-questionnaires. The answers to each test were first processed through a computer, then the patients were seen over the following weeks for the DIP-I and SCID-II semi-structured interviews. For both questionnaires, we only explored the diagnostic categories reaching pathological level (as was recommended by the authors). Considering the small number of patients involved, we used nonparametric tests: Wilcoxon test, Mac Nemar test and the Kappa.
As far as the self-questionnaire results are concerned, we noticed important differences for the schizoid and the schizotypic PD between the DIP-Q (ICD) and the DIP-Q (DSM). The most represented PDs are the paranoiac, borderline, avoiding and obsessional personalities. After the semi-structured interviews, it appears that only 30 to 50% of the diagnoses obtained through self-evaluation were confirmed (with the exception of the schizotypic personality and the antisocial personality for the SCID with perfect agreement between self and clinical evaluation). Globally, the agreement between diagnosis by self-evaluation and diagnosis by semi-structured interview is not very satisfactory. Finally, a cluster analysis of the results of the three semi-structured interviews put together reveals that five patients show at least one PD diagnosed in the three clusters, two have no diagnosis, six patients have one or several PDs in clusters B and C, three patients have some in clusters A and C, and five patients only have some in cluster C. Our results lead to several remarks: the size of our group is small, but it must be pointed out that the investigations for each patient took about three hours, which made it difficult for the patients to agree when the clinicians proposed the study; three patients originally included could not be evaluated because of suicidal behaviour. In their self-administered form, the SCID and the DSM version of the DIP-Q broadly diagnose a little more than three PDs per patient, whereas the ICD version of the DIP-Q diagnoses more than five. The administration of semi-structured interviews leads to an average of 1.3 diagnosis for the DIP-Q DSM-IV and 1.6 for the ICD against 1.9 PD for the SCID interview. These results correspond to the literature data. There are differences between the SCID and the DIP-I, as regards to the way they were used: the SCID-II makes it necessary to repeat the questions positively answered in the self-questionnaire, whereas the DIP-I explores all the criteria of the whole diagnosed PD, which may favour the inclusions. Concerning other instruments compared to the SCID-II in the international literature, our results with the DIP are globally satisfactory.
The results must be interpreted with some care, considering the small number of patients. Important discrepancies were noticed between the diagnoses obtained through self-evaluation and the semi-structured interview, mainly for the A and C personality clusters of the DSM-IV, showing the tests to be extremely sensitive, but not specific enough for detection. However, the agreement between both instruments referring to the DSM-IV is satisfactory. The main interest of our work was to make the first French translation of the DIP known and to compare it to another instrument, which has often been evaluated previously.
本研究旨在对两种可用于诊断人格障碍(PD)的标准化工具进行比较研究:即《精神疾病诊断与统计手册》第二版(SCID-II)和《人格障碍诊断问卷》(DIP)。这两种工具均采用自填问卷形式,随后由同一位临床医生进行半结构化访谈,并应用于21例人格障碍患者。最新的工具《人格障碍诊断问卷》(DIP,基于《精神疾病诊断与统计手册》第四版和《国际疾病分类》第十版)由博德伦德和奥托松创建,包括一份自填问卷(DIP-Q)和一份半结构化访谈(DIP-I)。它能够依据《精神疾病诊断与统计手册》第四版及《国际疾病分类》第十版的标准来评估人格障碍。我们将其翻译成法语,然后与另一种工具——由布瓦尔证明其有效性的《精神疾病诊断与统计手册》第四版轴II人格障碍结构化临床访谈(SCID-II)进行比较评估。
对于自填问卷(SCID-auto),我们使用了昆吉的计算机化版本。半结构化访谈SCID-E的当前版本(由布瓦尔等人进行法语翻译)评估了《精神疾病诊断与统计手册》第四版中的10种人格障碍、抑郁型人格和被动攻击型人格,这些内容包含在《精神疾病诊断与统计手册》第四版附录B中。DIP-Q问卷由140个是非题组成,涉及《精神疾病诊断与统计手册》第四版中的10种人格障碍以及《国际疾病分类》第十版中的8种障碍。DIP-I是奥托松等人创建的自结构化访谈,其结构与SCID-II相同。它可对所有《精神疾病诊断与统计手册》第四版和/或《国际疾病分类》第十版的人格障碍以及分裂型障碍进行诊断。在进行DIP-I之前,通常会先进行一次一般性的“筛查”访谈,以评估与《精神疾病诊断与统计手册》第四版或《国际疾病分类》第十版轴I相对应的现存人格障碍。在我们的研究中,我们用一份迷你国际神经精神访谈(MINI)问卷替代了这次访谈。圣艾蒂安大学精神病学中心医院的临床医生从门诊或住院患者中挑选出24例患有一种或多种人格障碍的患者。在研究过程中,检查人员不知道诊断结果。受试者填写了DIP-I和SCID-II自填问卷。每个测试的答案首先通过计算机进行处理,然后在接下来的几周内对患者进行DIP-I和SCID-II半结构化访谈。对于这两份问卷,我们仅探讨达到病理水平的诊断类别(正如作者所建议的那样)。考虑到参与的患者数量较少,我们使用了非参数检验:威尔科克森检验、麦克内马尔检验和卡帕检验。
就自填问卷结果而言,我们注意到DIP-Q(ICD)和DIP-Q(DSM)在分裂样和分裂型人格障碍方面存在重要差异。最常见的人格障碍类型是偏执型、边缘型、回避型和强迫型人格。在半结构化访谈之后,似乎通过自我评估获得的诊断中只有30%至50%得到了确认(分裂型人格和反社会人格在SCID中自我评估与临床评估完全一致的情况除外)。总体而言,自我评估诊断与半结构化访谈诊断之间的一致性不太令人满意。最后,对三次半结构化访谈结果进行的聚类分析表明,有5名患者在三个聚类中至少被诊断出有一种人格障碍,2名患者未被诊断出,6名患者在B聚类和C聚类中有一种或多种人格障碍,3名患者在A聚类和C聚类中有一些,5名患者仅在C聚类中有一些。我们的结果引发了几点看法:我们的研究小组规模较小,但必须指出的是,对每位患者的调查大约需要三个小时,这使得临床医生提出研究时患者很难同意参与;最初纳入的三名患者由于自杀行为无法进行评估。以自填形式,SCID和DIP-Q的DSM版本平均每位患者诊断出略多于三种人格障碍,而DIP-Q的ICD版本诊断出多于五种。半结构化访谈的结果显示,DIP-Q DSM-IV平均诊断出1.3种,ICD诊断出1.6种,而SCID访谈诊断出1.9种人格障碍。这些结果与文献数据相符。SCID和DIP-I在使用方式上存在差异:SCID-II需要重复在自填问卷中回答为肯定的问题,而DIP-I则探索整个诊断出的人格障碍的所有标准,这可能有利于诊断结果的纳入。与国际文献中与SCID-II相比的其他工具而言,我们使用DIP的结果总体上是令人满意的。
考虑到患者数量较少,对结果的解释必须谨慎。通过自我评估和半结构化访谈获得的诊断之间存在重要差异,主要体现在《精神疾病诊断与统计手册》第四版的A聚类和C聚类人格障碍上,这表明测试极其敏感,但检测的特异性不足。然而,两种工具在参照《精神疾病诊断与统计手册》第四版方面的一致性是令人满意的。我们这项工作的主要意义在于首次将DIP翻译成法语并与另一种此前经常被评估的工具进行比较。