Department of Family Medicine, Inha University College of Medicine, Incheon, Korea.
Alcohol. 2009 Dec;43(8):643-8. doi: 10.1016/j.alcohol.2009.10.005.
It is inconclusive whether moderate alcohol consumption reduces the diabetes risk. We observed the development of impaired fasting glucose or type 2 diabetes according to the amount of alcohol intake and body mass index. The annual health evaluation data of 2,500 male workers from 2002 to 2006 were reviewed retrospectively deleting personal identification code. The information contained sex, age, medical history, smoking status, alcohol consumption, participating regular exercise, anthropometric, and biochemistry measurement. Impaired fasting glucose or diabetes was determined when fasting plasma glucose was > or =100mg/dL. Thousand seven hundred seven subjects were eligible after excluding medical history of diabetes or fasting glucose > or =100mg/dL at baseline. The relative risks of its development in group of taking 1-14, 15-29, and > or =30.0g ethanol were 0.842 (95% confidence interval [CI], 0.603-1.176), 1.068 (95% CI, 0.736-1.551), and 1.019 (95% CI, 0.662-1.568) within normal weight group, 1.164 (95% CI, 0.795-1.705), 1.421 (95% CI, 0.947-2.133), and 1.604 (95% CI, 1.031-2.495) within overweight group, and 1.498 (95% CI, 1.042-2.153), 1.634 (95% CI, 1.091-2.447), and 1.563 (95% CI, 1.019-2.396) within obese group each after adjusting age, family history of diabetes, smoking, exercise, serum fasting glucose, aspartate aminotransferase, and gamma-glutamyltransferase with nondrinkers as a reference group. Not only high alcohol consumption but also moderate drinking was related with higher incidence of impaired fasting glucose or diabetes in obese Korean men.
目前，关于适量饮酒是否能降低糖尿病风险尚无定论。我们观察了根据饮酒量和体重指数（BMI）的不同，空腹血糖受损或 2 型糖尿病的发展情况。我们回顾性地分析了 2002 年至 2006 年 2500 名男性工人的年度健康评估数据，并删除了个人识别码。这些信息包括性别、年龄、病史、吸烟状况、饮酒量、定期运动、人体测量和生物化学测量。当空腹血糖≥100mg/dL 时，诊断为空腹血糖受损或糖尿病。排除基线时有糖尿病病史或空腹血糖≥100mg/dL 的患者后，1707 例患者符合条件。在体重正常组中，每天摄入 1-14、15-29 和≥30.0g 乙醇的个体发生上述疾病的相对风险分别为 0.842（95%可信区间 [CI]，0.603-1.176）、1.068（95% CI，0.736-1.551）和 1.019（95% CI，0.662-1.568），在超重组中，该比值分别为 1.164（95% CI，0.795-1.705）、1.421（95% CI，0.947-2.133）和 1.604（95% CI，1.031-2.495），在肥胖组中，该比值分别为 1.498（95% CI，1.042-2.153）、1.634（95% CI，1.091-2.447）和 1.563（95% CI，1.019-2.396）。以上比值均是在调整年龄、糖尿病家族史、吸烟、运动、血清空腹血糖、天冬氨酸转氨酶和γ-谷氨酰转移酶后，以不饮酒者为参照组得出的结果。在韩国肥胖男性中，不仅是大量饮酒，而且是适量饮酒也与空腹血糖受损或糖尿病的发病率升高有关。
