Lecomte P, Vol S, Cacès E, Born C, Chabrolle C, Lasfargues G, Halimi J-M, Tichet J
Unité d'endocrinologie et métabolisme, CHRU Bretonneau, 1 boulevard Tonnellé, 37044 Tours cedex 09, France.
Diabetes Metab. 2007 Apr;33(2):140-7. doi: 10.1016/j.diabet.2006.11.009. Epub 2007 Feb 22.
The outcome of 743 French men (age 20-60) with impaired fasting glucose (IFG) [blood glucose 6.1-6.9 mmol/l] at T1 was evaluated 5 years later, at T2.
Personal and family medical history, smoking, nutritional habits, physical activity, blood pressure, body mass index (BMI) and waist girth, fasting biological data were collected at T1 and T2. Predictive factors for developing diabetes were compared between those who returned to normal fasting glucose and those who had diabetes, before and after adjustment for age, BMI, glucose and triglyceride (TG) levels.
At T2, 44%, 39%, 17% were classified as normal fasting plasma glucose (FPG), IFG or diabetic, respectively. Odd ratios for diabetes were 4.2 for men with a family history of diabetes (FHD), 3.4 if BMI > or = 25 kg/m(2), 2.9 if waist girth > or = 90 cm, 2.8 if TG > or = 2 mmol/l and 1.9 if no daily dairy products were eaten. Still significant after adjustment for age, BMI, glucose and TG levels were: FHD (P=0.001), no daily dairy products (P=0.001), high alcohol intake (P=0.02) and low physical activity (P = 0.02).
No daily dairy products, high alcohol intake and low physical activity were independent predictive factors of a 5-year onset of diabetes after adjusting for BMI, FHD, triglyceride and glucose levels at baseline. For a better prevention of diabetes, these findings give clues for behaviour modifications as soon as IFG is detected.
对743名法国男性（年龄20 - 60岁）在T1时空腹血糖受损（IFG）[血糖6.1 - 6.9 mmol/l]的情况进行评估，5年后在T2时再次评估。
在T1和T2时收集个人和家族病史、吸烟情况、营养习惯、身体活动情况、血压、体重指数（BMI）和腰围、空腹生物学数据。比较空腹血糖恢复正常者和患糖尿病者在年龄、BMI、血糖和甘油三酯（TG）水平调整前后患糖尿病的预测因素。
在T2时，分别有44%、39%、17%被分类为空腹血糖正常（FPG）、IFG或糖尿病患者。有糖尿病家族史（FHD）的男性患糖尿病的比值比为4.2，BMI≥25 kg/m²时为3.4，腰围≥90 cm时为2.8，TG≥2 mmol/l时为2.9，不吃日常乳制品时为1.9。在年龄、BMI、血糖和TG水平调整后仍具有显著意义的因素有：FHD（P = 0.001）、不吃日常乳制品（P = 0.001）、高酒精摄入量（P = 0.02）和低身体活动量（P = 0.02）。
在对基线BMI、FHD、甘油三酯和血糖水平进行调整后，不吃日常乳制品、高酒精摄入量和低身体活动量是5年后患糖尿病的独立预测因素。为了更好地预防糖尿病，这些发现为一旦检测到IFG就进行行为改变提供了线索。
