细胞穿透性异戊烯化肽的序列和长度依赖性研究。
Investigation of the sequence and length dependence for cell-penetrating prenylated peptides.
机构信息
Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.
出版信息
Bioorg Med Chem Lett. 2010 Jan 1;20(1):161-3. doi: 10.1016/j.bmcl.2009.11.026. Epub 2009 Nov 13.
Abstract
Cell penetrating peptides are useful delivery tools for introducing molecules of interest into cells. A new class of cell penetrating molecules has been recently reported-cell penetrating, prenylated peptides. In this study a series of such peptides was synthesized to examine the relationship between peptide sequence and level of peptide internalization and to probe their mechanism of internalization. This study revealed that prenylated peptides internalize via a non-endocytotic pathway regardless of sequence. Sequence length and identity was found to play a role in peptide uptake but prenylated sequences as short as two amino acids were found to exhibit significant cell penetrating properties.
摘要
细胞穿透肽是将感兴趣的分子导入细胞的有用的传递工具。最近报道了一类新的细胞穿透分子 - 细胞穿透， prenylated 肽。在这项研究中，合成了一系列这样的肽，以研究肽序列与肽内化水平之间的关系，并探究其内化机制。本研究表明，prenylated 肽通过非胞吞途径内化，与序列无关。序列长度和同一性被发现对肽摄取起作用，但发现短至两个氨基酸的 prenylated 序列表现出显著的细胞穿透特性。
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本文引用的文献
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