Université de Bordeaux, Unité Mixte de Recherche-Centre National de la Recherche Scientifique (UMR-CNRS) 5227, 146 rue Léo Saignat, B.P. 28, 33076 Bordeaux Cedex, France.
Neurosci Lett. 2010 Jan 22;469(2):251-5. doi: 10.1016/j.neulet.2009.12.006. Epub 2009 Dec 11.
Serotonin(2C) (5-HT(2C)) receptors are widely expressed in the basal ganglia, a group of brain regions involved in the control of motor behavior. However, it remains unclear whether their tonic influence on neuronal activity is distributed in these regions. We have addressed this question by measuring the product of the proto-oncogene c-Fos in rats after peripheral administration of the non-selective 5-HT antagonist mianserin, the 5-HT(2C/2B) antagonist SER-082 or the selective 5-HT(2C) antagonist SB 243213. The intraperitoneal administration of 1mg/kg of SB 243213 or SER-082, but not mianserin, enhanced Fos-immunoreactive cells in the subthalamic nucleus and the striatum, primarily its medial portion. None of these treatments significantly affected Fos expression in the external globus pallidus, the entopeduncular nucleus (the internal globus pallidus in primate) or the substantia nigra pars reticulata. The data suggest that selective blockade of 5-HT(2C) receptors is necessary to unmask a tonic regulation of neuronal activity by this receptor in the basal ganglia and that this effect is restricted to the two structures receiving cortical entries, the striatum and the subthalamic nucleus.
血清素(2C)(5-HT(2C))受体广泛表达于基底神经节，这是一组参与运动行为控制的脑区。然而，其对神经元活动的紧张性影响是否分布于这些区域尚不清楚。我们通过测量大鼠外周给予非选择性 5-HT 拮抗剂米氮平、5-HT(2C/2B)拮抗剂 SER-082 或选择性 5-HT(2C)拮抗剂 SB 243213 后原癌基因 c-Fos 的产物，来解决这个问题。腹腔内给予 1mg/kg 的 SB 243213 或 SER-082，但不是米氮平，增强了苍白球外侧部(subthalamic nucleus)和纹状体(striatum)、主要是其内侧部分的 Fos-免疫反应细胞。这些处理方法均未显著影响外苍白球(globus pallidus externus)、脚间核(entopeduncular nucleus，灵长类动物的内苍白球)或黑质网状部(substantia nigra pars reticulata)中的 Fos 表达。数据表明，选择性阻断 5-HT(2C)受体是揭示该受体在基底神经节中对神经元活动的紧张性调节所必需的，并且这种效应仅限于接收皮质传入的两个结构，即纹状体和苍白球内侧部。
