Department of Neurology, Erasmus Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
Pediatr Neurol. 2010 Jan;42(1):53-5. doi: 10.1016/j.pediatrneurol.2009.07.013.
We sought to identify clinical and radiologic features predicting early relapse after a diagnosis of multiple sclerosis in children. In this nationwide retrospective multicenter study in The Netherlands, we included 28 children with multiple sclerosis with onset before age 16 years. Magnetic resonance images and clinical features at the onset of disease were evaluated. The mean follow-up time was 55 months. Twenty children (71%) had a relapse during follow-up. We found that the presence of at least three of four Barkhof magnetic resonance imaging criteria at the onset of multiple sclerosis signs is predictive of early relapse after a diagnosis of multiple sclerosis in children (P<0.05).
我们旨在确定儿童多发性硬化症诊断后早期复发的临床和影像学特征。在荷兰进行的这项全国性回顾性多中心研究中，我们纳入了 28 名发病年龄在 16 岁以下的多发性硬化症患儿。评估了疾病发病时的磁共振成像和临床特征。平均随访时间为 55 个月。20 名患儿（71%）在随访期间复发。我们发现，多发性硬化症发病时存在至少四项 Barkhof 磁共振成像标准中的四项，可预测儿童多发性硬化症诊断后的早期复发（P<0.05）。
