Department of Psychology, University of California, Berkeley, CA 94720-1650, USA.
J Behav Ther Exp Psychiatry. 2010 Jun;41(2):145-9. doi: 10.1016/j.jbtep.2009.11.007. Epub 2009 Dec 1.
We investigated associations between sleep, illness course, and concurrent symptoms in 21 participants with bipolar disorder who were inter-episode. Sleep was assessed using a week-long diary. Illness course and symptoms were assessed via validated semi-structured interviews. Lower and more variable sleep efficiency and more variable total wake time were associated with more lifetime depressive episodes. Variability in falling asleep time was positively correlated with concurrent depressive symptoms. Sleep efficiency was positively correlated with concurrent manic symptoms. These findings suggest that inter-episode sleep disturbance is associated with illness course and that sleep may be an important intervention target in bipolar disorder.
我们调查了 21 名处于缓解期的双相情感障碍患者的睡眠、疾病进程和并发症状之间的关联。使用为期一周的日记评估睡眠。通过经过验证的半结构化访谈评估疾病过程和症状。较低且更可变的睡眠效率和更多变的总清醒时间与更多的终生抑郁发作有关。入睡时间的可变性与并发抑郁症状呈正相关。睡眠效率与并发躁狂症状呈正相关。这些发现表明缓解期睡眠障碍与疾病进程有关，睡眠可能是双相情感障碍的一个重要干预靶点。
