Department of Regenerative Medicine Science, Tokai University School of Medicine, Isehara, Japan.
Trends Cardiovasc Med. 2009 Jul;19(5):170-3. doi: 10.1016/j.tcm.2009.10.002.
It is generally accepted that endothelial progenitor cells (EPCs) can promote postnatal neovascularization and be used for vascular regeneration, thus representing a promising new tool for the treatment of cardiovascular diseases. However, the exact molecular mechanisms and signaling pathways regulating the proliferation, differentiation, and migration of EPCs; their interaction with niche cells; and their regenerative capacity still remain elusive. The Notch signaling pathway shown to be important for the maintenance and differentiation of various stem and progenitor populations is also involved in EPC regulation. In this review, we will summarize the current knowledge about the pivotal role of Notch signaling in EPC biology and EPC-mediated vascular regeneration.
人们普遍认为内皮祖细胞（EPCs）可以促进出生后新生血管形成，并可用于血管再生，因此代表了一种有前途的心血管疾病治疗新工具。然而，调节 EPC 增殖、分化和迁移的确切分子机制和信号通路；它们与龛细胞的相互作用；以及它们的再生能力仍然难以捉摸。 Notch 信号通路被证明对各种干细胞和祖细胞群体的维持和分化很重要，也参与了 EPC 的调节。在这篇综述中，我们将总结 Notch 信号在 EPC 生物学和 EPC 介导的血管再生中的关键作用的最新知识。
