内皮祖细胞：预防心血管疾病的新靶点。

Endothelial progenitor cells: a new target for the prevention of cardiovascular diseases.

作者信息

Brixius Klara, Funcke Fabienne, Graf Christine, Bloch Wilhelm

机构信息

Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.

出版信息

Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):705-10. doi: 10.1097/01.hjr.0000221862.34662.31.

DOI:10.1097/01.hjr.0000221862.34662.31

PMID:17001208

Abstract

Endothelial progenitor cells (EPCs) are circulating precursor cells that have been implicated recently in vascular and cardiac regeneration. There is an ongoing discussion on the immunocytological definition of EPCs, based on various surface markers, and currently different cell types are included in the term 'EPC'. This review summarizes the mechanisms that influence function, survival, mobilization and differentiation of EPCs. Furthermore, there are several reports on the clinical use of EPCs for the treatment of cardiovascular diseases. We have focused specifically on the influence of physical activity on EPC function.

摘要

内皮祖细胞（EPCs）是循环前体细胞，最近被认为与血管和心脏再生有关。基于各种表面标志物，目前关于EPCs的免疫细胞定义仍在讨论中，并且“EPC”一词目前包含不同的细胞类型。这篇综述总结了影响EPCs功能、存活、动员和分化的机制。此外，有几篇关于EPCs在治疗心血管疾病方面临床应用的报道。我们特别关注了体育活动对EPCs功能的影响。