人类免疫缺陷病毒相关性肾病的治疗。
The treatment of HIV-associated nephropathy.
机构信息
MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA.
出版信息
Adv Chronic Kidney Dis. 2010 Jan;17(1):59-71. doi: 10.1053/j.ackd.2009.08.013.
Abstract
Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is associated in part with suppression of HIV-1 viral replication. The extent to which the response to ART differs in persons with HIVAN compared with those with other HIV-associated kidney disorders is unknown. Beneficial effects of corticosteroids and angiotensin-converting enzyme inhibitors on kidney function also are suggested by retrospective cohort studies and uncontrolled trials of patients with HIVAN. Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy.
摘要
抗逆转录病毒疗法（ART）可维持人类免疫缺陷病毒（HIV）相关性肾病（HIVAN）患者的肾脏功能。新出现的数据还表明，ART 在一般 HIV 感染人群中也具有显著的肾脏益处，这部分归因于抑制 HIV-1 病毒复制。与其他 HIV 相关肾脏疾病患者相比，HIVAN 患者对 ART 的反应程度存在差异，目前尚不清楚。回顾性队列研究和对 HIVAN 患者的非对照试验也提示皮质类固醇和血管紧张素转换酶抑制剂对肾脏功能具有有益作用。慢性肾脏病（CKD）合并 HIV 感染患者的 ART 治疗不足或剂量不足，可能会限制从这种治疗中获得的最佳获益。
相似文献
1
The treatment of HIV-associated nephropathy.人类免疫缺陷病毒相关性肾病的治疗。
Adv Chronic Kidney Dis. 2010 Jan;17(1):59-71. doi: 10.1053/j.ackd.2009.08.013.
2
Pharmacotherapy for human immunodeficiency virus-associated nephropathy.人类免疫缺陷病毒相关性肾病的药物治疗
Pharmacotherapy. 2005 Dec;25(12):1761-72. doi: 10.1592/phco.2005.25.12.1761.
3
Long-term renal survival in HIV-associated nephropathy with angiotensin-converting enzyme inhibition.血管紧张素转换酶抑制剂治疗HIV相关性肾病的长期肾脏存活率
Kidney Int. 2003 Oct;64(4):1462-71. doi: 10.1046/j.1523-1755.2003.00230.x.
4
HIVAN and medication use in chronic dialysis patients in the United States: analysis of the USRDS DMMS Wave 2 study.美国慢性透析患者中的HIV相关性肾病与药物使用：美国肾脏数据系统糖尿病微血管病变研究第2波分析
BMC Nephrol. 2003 Jul 1;4:5. doi: 10.1186/1471-2369-4-5.
5
HIV-associated renal disorders: recent insights into pathogenesis and treatment.HIV相关性肾脏疾病：发病机制与治疗的最新见解
Curr HIV/AIDS Rep. 2005 Aug;2(3):109-15. doi: 10.1007/s11904-005-0002-x.
6
[Inhibition of the renin-angiotensin system in HIV nephropathy].
G Ital Nefrol. 2014 Jan-Feb;31(1).
7
[HIV-related nephropathy: epidemiologic and therapeutic aspects].[与人类免疫缺陷病毒相关的肾病：流行病学及治疗方面]
Nephrologie. 2001;22(6):299-300.
8
Interventions for HIV-associated nephropathy.人类免疫缺陷病毒相关性肾病的干预措施。
Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD007183. doi: 10.1002/14651858.CD007183.pub3.
9
Captopril and renal survival in patients with human immunodeficiency virus nephropathy.卡托普利与人类免疫缺陷病毒肾病患者的肾脏存活情况
Am J Kidney Dis. 1996 Aug;28(2):202-8. doi: 10.1016/s0272-6386(96)90302-9.
10
Acute renal failure secondary to HIVAN despite HAART: a possible pathogenic role for cytomegalovirus.
Nephrology (Carlton). 2007 Feb;12(1):108-9. doi: 10.1111/j.1440-1797.2006.00750.x.
引用本文的文献
1
Urinary lipoarabinomannan in individuals with sputum-negative pulmonary tuberculosis.痰菌阴性肺结核患者的尿液脂阿拉伯甘露聚糖。
Indian J Med Res. 2024 Feb 1;159(2):206-212. doi: 10.4103/ijmr.ijmr_2074_22. Epub 2024 Apr 4.
2
The changing landscape of HIV-associated kidney disease.与艾滋病相关的肾脏疾病不断变化的形势。
Nat Rev Nephrol. 2024 May;20(5):330-346. doi: 10.1038/s41581-023-00801-1. Epub 2024 Jan 25.
3
Effect of tenofovir containing ART on renal function in patients with moderate/severe reduced creatinine clearance at baseline: A retrospective study at two referral hospitals in Namibia.基线时肌酐清除率中度/重度降低的患者中含替诺福韦的 ART 对肾功能的影响：纳米比亚两家转诊医院的回顾性研究。
Pharmacol Res Perspect. 2023 Feb;11(1):e00681. doi: 10.1002/prp2.681.
4
A Case of Focal Segmental Glomerulosclerosis With Immune Complexes: Is HIV, Hepatitis B, or Crack the Culprit?一例伴有免疫复合物的局灶节段性肾小球硬化症：是HIV、乙型肝炎还是强效可卡因所致？
Cureus. 2021 Aug 20;13(8):e17335. doi: 10.7759/cureus.17335. eCollection 2021 Aug.
5
Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity.HIV 阴性肺结核患者尿液中的脂阿拉伯甘露聚糖聚糖与疾病严重程度相关。
Sci Transl Med. 2017 Dec 13;9(420). doi: 10.1126/scitranslmed.aal2807.
6
Impact of Moringa oleifera lam. Leaf powder supplementation versus nutritional counseling on the body mass index and immune response of HIV patients on antiretroviral therapy: a single-blind randomized control trial.辣木叶片粉补充剂与营养咨询对接受抗逆转录病毒治疗的HIV患者体重指数和免疫反应的影响：一项单盲随机对照试验。
BMC Complement Altern Med. 2017 Aug 22;17(1):420. doi: 10.1186/s12906-017-1920-z.
7
Update on current management of chronic kidney disease in patients with HIV infection.HIV感染患者慢性肾脏病当前管理的最新进展
Int J Nephrol Renovasc Dis. 2016 Sep 16;9:223-234. doi: 10.2147/IJNRD.S93887. eCollection 2016.
8
Multiple facets of HIV-associated renal disease.HIV相关性肾病的多个方面。
Braz J Med Biol Res. 2016;49(4):e5176. doi: 10.1590/1414-431X20165176. Epub 2016 Mar 18.
9
Renal Function in Chinese HIV-Positive Individuals following Initiation of Antiretroviral Therapy.接受抗逆转录病毒治疗的中国HIV阳性个体的肾功能
PLoS One. 2015 Aug 28;10(8):e0135462. doi: 10.1371/journal.pone.0135462. eCollection 2015.
10
African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era.人类免疫缺陷病毒时代的非洲起源与慢性肾脏病易感性
World J Nephrol. 2015 May 6;4(2):295-306. doi: 10.5527/wjn.v4.i2.295.
本文引用的文献
1
2
HIV viremia and changes in kidney function.HIV病毒血症与肾功能变化。
AIDS. 2009 Jun 1;23(9):1089-96. doi: 10.1097/QAD.0b013e32832a3f24.
3
Interruption of antiretroviral therapy is associated with increased plasma cystatin C.抗逆转录病毒疗法的中断与血浆胱抑素C升高有关。
AIDS. 2009 Jan 2;23(1):71-82. doi: 10.1097/QAD.0b013e32831cc129.
4
Immune complex renal disease and human immunodeficiency virus infection.免疫复合物性肾病与人类免疫缺陷病毒感染
Semin Nephrol. 2008 Nov;28(6):535-44. doi: 10.1016/j.semnephrol.2008.08.006.
5
Kidney disease in patients with HIV infection and AIDS.感染HIV和患艾滋病患者的肾脏疾病
Clin Infect Dis. 2008 Dec 1;47(11):1449-57. doi: 10.1086/593099.
6
Baseline renal insufficiency and risk of death among HIV-infected adults on antiretroviral therapy in Lusaka, Zambia.赞比亚卢萨卡接受抗逆转录病毒治疗的HIV感染成人的基线肾功能不全与死亡风险
AIDS. 2008 Sep 12;22(14):1821-7. doi: 10.1097/QAD.0b013e328307a051.
7
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel.成人HIV感染的抗逆转录病毒治疗：美国国际艾滋病协会专家组2008年建议
JAMA. 2008 Aug 6;300(5):555-70. doi: 10.1001/jama.300.5.555.
8
Antiretroviral therapy improves renal function among HIV-infected Ugandans.抗逆转录病毒疗法可改善乌干达HIV感染者的肾功能。
Kidney Int. 2008 Oct;74(7):925-9. doi: 10.1038/ki.2008.305. Epub 2008 Jul 9.
9
Predictors of renal outcome in HIV-associated nephropathy.HIV相关性肾病的肾脏预后预测因素
Clin Infect Dis. 2008 Apr 15;46(8):1282-9. doi: 10.1086/529385.
10
Severe renal dysfunction and risk factors associated with renal impairment in HIV-infected adults in Africa initiating antiretroviral therapy.非洲开始接受抗逆转录病毒治疗的HIV感染成人的严重肾功能不全及与肾功能损害相关的危险因素。
Clin Infect Dis. 2008 Apr 15;46(8):1271-81. doi: 10.1086/533468.
Zotero 插件