Hofsli E
Institutt for kreftforskning, Kreftavdelingen, Regionsykehuset i Trondheim.
Tidsskr Nor Laegeforen. 1991 Jan 10;111(1):37-40.
Chemotherapy plays an important role in the treatment of cancer. However, the drug regimens used today can only offer a cure to a small fraction of cancer patients. The article reviews the factors that limit the effect of chemotherapeutic treatment of cancer. The major cause of failure of chemotherapeutic treatment is the presence of resistant tumour cells. In addition to the various changes that may occur in tumour cells, various other factors may limit the "effective concentration" of a drug delivered to the site of the tumour, and thereby affect the overall clinical response to therapy.
化疗在癌症治疗中发挥着重要作用。然而，如今使用的药物方案仅能治愈一小部分癌症患者。本文综述了限制癌症化疗效果的因素。化疗失败的主要原因是存在耐药肿瘤细胞。除了肿瘤细胞可能发生的各种变化外，其他各种因素可能会限制输送到肿瘤部位的药物“有效浓度”，从而影响治疗的总体临床反应。
