Combat Care Laboratory, Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, #12-00, Singapore 117510, Singapore.
Mitochondrion. 2010 Mar;10(2):83-93. doi: 10.1016/j.mito.2009.12.142. Epub 2009 Dec 22.
Gasomodulators - nitric oxide, carbon monoxide and hydrogen sulphide - are important physiological mediators that have been implicated in disorders such as neurodegeneration and sepsis. Some of their biological functions involve the mitochondria. In particular, their inhibition of cytochrome c oxidase has received much attention as this can cause energy depletion and cytotoxicity. However, reports that cellular energy production and cell survival are maintained even in the presence of gasomodulators are not uncommon. In both cases, modulation of mitochondrial targets by the gasomodulators appears to be an important event. We provide an overview of the effects of the gasomodulators on the mitochondria.
气体调质物——一氧化氮、一氧化碳和硫化氢——是重要的生理介质，它们与神经退行性疾病和败血症等疾病有关。它们的一些生物学功能涉及线粒体。特别是，它们对细胞色素 c 氧化酶的抑制作用引起了广泛关注，因为这会导致能量耗竭和细胞毒性。然而，即使存在气体调质物，细胞能量产生和细胞存活也能维持的报道并不罕见。在这两种情况下，气体调质物对线粒体靶标的调节似乎是一个重要事件。我们提供了气体调质物对线粒体影响的概述。
