Zhang Ka, Zhu Yi-Wen, Tang Ao-Qi, Zhou Ze-Tao, Yang Yi-Lun, Liu Zi-Hui, Li Yan, Liang Xiao-Yi, Feng Zhi-Fen, Wang Jun, Jiang Tong, Jiang Qi-Ying, Wu Dong-Dong
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan 475004, China; School of Clinical Medicine, Henan University, Kaifeng, Henan 475004, China.
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan 475004, China; Department of Stomatology, Huaihe Hospital of Henan University, School of Stomatology, Henan University, Kaifeng, Henan 475004, China.
Transl Oncol. 2025 Feb;52:102272. doi: 10.1016/j.tranon.2025.102272. Epub 2025 Jan 14.
The occurrence and development of tumor is mediated by a wide range of complex mechanisms. Subsequent to nitric oxide and carbon monoxide, hydrogen sulfide (HS) holds the distinction of being the third identified gasotransmitter. Alternation of HS level has been widely demonstrated to induce an array of disturbances in important cancer cell signaling pathways. As a result, the effects of HS-catalyzing enzymes in cancers also attract widspread attention. 3-mercaptopyruvate sulfurtransferase (3-MST) is privileged to be one of them. In fact, 3-MST is overexpressed in many tumors including human colon cancer, lung adenocarcinoma, and bladder urothelial carcinoma. But it is also lowly expressed in hepatocellular carcinoma. In this review, we focus on the generation of endogenous HS and polysulfides, facilitated by 3-MST. Additionally, we delve deeply into the potential role of 3-MST in tumorigenesis and development. The impact of 3-MST inhibition on the development of tumors and its potential for tumor therapy are also highlighted.
肿瘤的发生和发展是由多种复杂机制介导的。继一氧化氮和一氧化碳之后，硫化氢（HS）成为第三种被发现的气体信号分子。大量研究表明，HS水平的改变会在重要的癌细胞信号通路中引发一系列紊乱。因此，HS催化酶在癌症中的作用也引起了广泛关注。3-巯基丙酮酸硫转移酶（3-MST）就是其中之一。事实上，3-MST在许多肿瘤中都有过表达，包括人类结肠癌、肺腺癌和膀胱尿路上皮癌。但在肝细胞癌中它的表达也较低。在这篇综述中，我们聚焦于由3-MST促进的内源性HS和多硫化物的生成。此外，我们深入探讨了3-MST在肿瘤发生和发展中的潜在作用。还强调了抑制3-MST对肿瘤发展的影响及其在肿瘤治疗中的潜力。
