Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People's Republic of China, Heilongjiang University, Xuefu Road 74, Harbin 150080, Nangang District, Heilongjiang, PR China.
Talanta. 2010 Jan 15;80(3):1378-84. doi: 10.1016/j.talanta.2009.09.039.
Based on combination of chiral recognition ability of beta-cyclodextrin (beta-CD) derivatives and flexibility of monolithic material, a series of chiral stationary phases (CSPs) were prepared by the immobilization of beta-CD and three of its derivatives to the epoxy-activated poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith under mild condition. Immobilization condition for the connection reaction by different functional groups and bonding ways was studied to obtain good enantiomer selectivity. Prepared CSPs were evaluated by separating racemic mixtures of eight amino acids and two chiral drugs with capillary electrochromatography (CEC).
基于β-环糊精（β-CD）衍生物的手性识别能力和整体材料的柔韧性，通过在温和条件下将β-CD 及其三种衍生物固定到环氧活化的聚（甲基丙烯酸缩水甘油酯-共聚-乙二醇二甲基丙烯酸酯）整体材料上，制备了一系列手性固定相（CSP）。研究了不同官能团和键合方式的连接反应的固定化条件，以获得良好的对映体选择性。通过毛细管电色谱（CEC）分离 8 种氨基酸和 2 种手性药物的外消旋混合物对制备的 CSP 进行了评价。
