Brinch L, Evensen S A, Albrechtsen D, Egeland T
Medisinsk avdeling A, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1991 Jan 30;111(3):316-9.
Marrow ablation with cytotoxic drugs and/or total body irradiation followed by allogeneic bone marrow transplantation from an HLA-identical sibling cures many patients with acute and chronic myeloid leukaemia. We have obtained good results with this treatment. Up to now the necessary funds to cover the minimal requirements for transplantations in Norway have not been granted. It is now possible to use unrelated, HLA-matched donors, which will more than double the need for allogeneic bone marrow transplantations within a few years. This article discusses indications, results, costs and practical procedures connected to allogeneic bone marrow transplantation for leukaemia in adults.
使用细胞毒性药物和/或全身照射进行骨髓消融,随后接受来自 HLA 匹配同胞的异基因骨髓移植,可治愈许多急性和慢性髓细胞白血病患者。我们采用这种治疗方法已取得了良好的效果。到目前为止,挪威用于满足移植最低需求的必要资金尚未获批。现在可以使用不相关的 HLA 匹配供体,这将在几年内使异基因骨髓移植的需求增加一倍多。本文讨论了与成人白血病异基因骨髓移植相关的适应症、结果、成本和实际操作程序。