Canadian Forces Health Services, Tory Regional Trauma Centre and the Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada M4N 3M5.
Am J Emerg Med. 2010 Jan;28(1):120.e1-5. doi: 10.1016/j.ajem.2009.04.027.
Recent military experience suggests that transfusing fresh frozen plasma and packed red cells in a 1:1 ratio may improve survival in exsanguinating trauma patients. We report the case of a single patient who required massive transfusion after suffering a single gunshot wound. Initially, the patient received FFP:PRBC in 1:2 ratio, but this did not correct laboratory parameters except for INR and clotting factor VII level, which were likely normalized by treatment with recombinant activated factor VII. After receiving FFP:PRBC in a 4:5 ratio, he continued to bleed and his coagulation profile showed no appreciable improvement. In the final phase, he received FFP:PRBC in a 7:5 ratio and his laboratory parameters of coagulopathy normalized, except for factor V level which was improved. He also clinically stopped bleeding.
近期的军事经验表明，以 1:1 的比例输注新鲜冰冻血浆和浓缩红细胞可能会提高出血性创伤患者的存活率。我们报告了 1 例因单发枪伤而大量输血的患者。最初，该患者接受了 FFP:PRBC 为 1:2 的比例，但除了 INR 和凝血因子 VII 水平外，这并没有纠正实验室参数，而 INR 和凝血因子 VII 水平可能通过重组活化因子 VII 的治疗而正常化。接受 FFP:PRBC 为 4:5 的比例后，他继续出血，他的凝血谱没有明显改善。在最后阶段，他接受了 FFP:PRBC 为 7:5 的比例，他的凝血功能障碍的实验室参数正常化，除了因子 V 水平有所改善。他也在临床上停止了出血。
