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长期护理医院环境中血液透析患者的结局:一项单中心研究。

Outcomes of hemodialysis patients in a long-term care hospital setting: a single-center study.

机构信息

Cincinnati VA Medical Center, Cincinnati, OH, USA.

出版信息

Am J Kidney Dis. 2010 Feb;55(2):300-6. doi: 10.1053/j.ajkd.2009.08.021. Epub 2009 Dec 16.

Abstract

BACKGROUND

Long-term care hospitals (LTCHs) provide intermediary care after an acute-care hospitalization and usually furnish care to patients with complex medical problems. Outcomes of hemodialysis patients admitted to LTCHs, which includes patients with either end-stage renal disease (ESRD) or acute kidney injury (AKI) requiring dialysis therapy, are not known.

STUDY DESIGN

Observational study.

SETTING & PARTICIPANTS: All consecutive hemodialysis patients admitted to an LTCH.

PREDICTORS

Demographic characteristics, comorbid and laboratory variables, ESRD, and AKI status during LTCH stay.

OUTCOMES

Disposition from LTCHs was classified as discharge to home, nursing home, death in LTCH or hospice care, and re-admission to the hospital. In patients with AKI, renal recovery was defined as discontinuation of dialysis therapy before meeting disposition outcomes.

RESULTS

96 of 206 (46.6%) patients had ESRD, whereas 110 of 206 (53.3%) developed AKI requiring dialysis therapy during the acute-care hospitalization. 63 of 206 (31%) were discharged to home, 11 of 206 (5.4%) died or transferred to hospice, 81 of 206 (40%) went to a nursing home, and 49 of 206 (24%) were re-admitted to a hospital; mortality after re-admission was 32%. Older age (OR, 0.96; 95% CI, 0.93-0.98), diabetes mellitus (OR, 0.45; 95% CI, 0.23-0.94), number of re-admissions to the hospital (OR, 0.38; 95% CI, 0.18-0.78), aminoglycoside use (OR, 0.16; 95% CI, 0.04-0.64), and duration of hospitalization before LTCH admission (OR, 0.96; 95% CI, 0.94-0.99) were associated with lower odds of discharge to home. Of 110 patients with AKI requiring dialysis therapy, 30% (33 patients) discontinued dialysis therapy, whereas 70% were deemed to have ESRD on discharge.

LIMITATIONS

Retrospective observational study.

CONCLUSIONS

Most dialysis patients at LTCHs are either re-admitted to acute-care hospitals or require nursing home placement. Only 30% of patients with AKI recover sufficiently to discontinue dialysis therapy, whereas 70% are deemed to have ESRD.

摘要

背景

长期护理医院(LTCH)为急性住院治疗后提供中间护理,通常为患有复杂医疗问题的患者提供护理。接受 LTCH 治疗的血液透析患者的结局尚不清楚,这些患者包括终末期肾脏疾病(ESRD)或需要透析治疗的急性肾损伤(AKI)患者。

研究设计

观察性研究。

地点和参与者

所有连续入住 LTCH 的血液透析患者。

预测因素

人口统计学特征、合并症和实验室变量、LTCH 住院期间的 ESRD 和 AKI 状况。

结局

LTCH 的处置方式分为出院回家、疗养院、LTCH 死亡或临终关怀、以及再次入院。在 AKI 患者中,肾功能恢复定义为在达到处置结局之前停止透析治疗。

结果

206 名患者中有 96 名(46.6%)患有 ESRD,而 206 名患者中有 110 名(53.3%)在急性住院期间发生需要透析治疗的 AKI。206 名患者中有 63 名(31%)出院回家,206 名患者中有 11 名(5.4%)死亡或转至临终关怀,206 名患者中有 81 名(40%)入住疗养院,206 名患者中有 49 名(24%)再次入院;再次入院后的死亡率为 32%。年龄较大(OR,0.96;95%CI,0.93-0.98)、患有糖尿病(OR,0.45;95%CI,0.23-0.94)、多次再次入院(OR,0.38;95%CI,0.18-0.78)、使用氨基糖苷类药物(OR,0.16;95%CI,0.04-0.64)和 LTCH 入院前住院时间(OR,0.96;95%CI,0.94-0.99)与较低的出院回家几率相关。在 110 名需要透析治疗的 AKI 患者中,有 30%(33 名患者)停止了透析治疗,而 70%的患者在出院时被认为患有 ESRD。

局限性

回顾性观察性研究。

结论

LTCH 中的大多数透析患者要么再次入院到急性护理医院,要么需要入住疗养院。只有 30%的 AKI 患者肾功能恢复足以停止透析治疗,而 70%的患者被认为患有 ESRD。

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