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[儿童细菌性脑膜炎治疗期间的发热]

[Fever during treatment for bacterial meningitis in children].

作者信息

Madsen L P, Christensen K R, Lund H T

机构信息

Randers Centralsygehus, paediatrisk afdeling.

出版信息

Ugeskr Laeger. 1991 Feb 11;153(7):512-4.

PMID:2000666
Abstract

Eighty-seven infants and children aged 1 month to 15 years admitted to the Pediatric Department, Randers Central Hospital 1975-1988 with bacterial meningitis were evaluated with special interest in the course of fever and its relation to sequelae. The children were treated with ampicillin (400 mg/kg/day). We found that 94% were afebrile after six days. 10% had persisting fever, 1% prolonged fever and 38% were found to develop secondary fever. Significantly more children infected with H. Influenzae had secondary fever. In most cases, no reason for secondary fever was found (46%). 18% had drug fever and only one case of relapse was found. 23% had severe sequelae. No significant relationships between persistent, prolonged or secondary fever and sequelae were found.

摘要

1975年至1988年间,兰讷斯中心医院儿科收治了87名年龄在1个月至15岁之间的患有细菌性脑膜炎的婴幼儿及儿童,对其发热过程及其与后遗症的关系进行了特别评估。这些儿童接受氨苄青霉素治疗(400毫克/千克/天)。我们发现,94%的儿童在六天后不再发热。10%的儿童持续发热,1%的儿童发热时间延长,38%的儿童出现继发性发热。感染流感嗜血杆菌的儿童出现继发性发热的比例明显更高。在大多数情况下,未发现继发性发热的原因(46%)。18%的儿童出现药物热,仅发现1例复发。23%的儿童有严重后遗症。未发现持续发热、发热时间延长或继发性发热与后遗症之间存在显著关系。

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