Hults Gata 98, S-436 44 ASKIM Gothenburg-Askim, Sweden.
Prog Neurobiol. 2010 Feb 9;90(2):119-45. doi: 10.1016/j.pneurobio.2009.11.004. Epub 2009 Dec 14.
The review describes the initial experiments suggesting a fast intra-axonal transport of transmitter related substances, in addition to the "classic" slow flow. Early experiments were mainly conducted in the peripheral adrenergic system, focusing on transport of amine storage granules, the extent of the vast sympathetic adrenergic system and the importance of axonal transport of amine granules for the adrenergic system. Further, it describes important advances obtained from studies of other neuron systems regarding local axonal protein synthesis, motor proteins and new insights regarding relation between faults in the transport machinery and some neuropathological conditions.
该综述描述了最初的实验结果，表明除了“经典”的慢速流动外，还有一种快速的轴内递质相关物质转运。早期实验主要集中在外周肾上腺素能系统，研究对象是胺储存颗粒的转运、庞大的交感肾上腺素能系统的范围，以及胺颗粒的轴内转运对肾上腺素能系统的重要性。此外，它还描述了从其他神经元系统的研究中获得的重要进展，包括局部轴突蛋白合成、运动蛋白，以及在运输机制故障与某些神经病理学状况之间的关系方面的新见解。
