School of Chemistry and Chemical Biology University College Dublin, Belfield, Dublin 4, Ireland.
Int J Pharm. 2010 Mar 30;388(1-2):213-22. doi: 10.1016/j.ijpharm.2009.12.003. Epub 2009 Dec 16.
High-resolution ultrasonic spectroscopy was applied to analyse a pseudo-ternary phase diagram for a mixture consisting of water/ethyl oleate/Tween 80 and Span 20 at 25 degrees C. The measured changes in the ultrasonic velocity and attenuation with concentration of water in oil/surfactants mixtures showed several, well defined stages and transitions between them, which allowed construction of an 'ultrasonic' phase diagram. Quantitative analysis of the ultrasonic parameters enabled characterisation of various phases (microemulsion, liquid crystals and pseudo-bicontinuous) as well as evaluation of the state of the water and particle size in microemulsion phase.
高分辨率超声光谱法被应用于分析 25°C 下由水/油酸乙酯/Tween 80 和 Span 20 组成的假三元相图。测量的超声速度和衰减随油/表面活性剂混合物中水浓度的变化显示出几个明确的阶段和它们之间的转变，这允许构建一个“超声”相图。超声参数的定量分析能够表征各种相（微乳液、液晶和拟双连续相）以及评估微乳液相中水的状态和颗粒尺寸。
