痘病毒搭乘肌动蛋白：已知硬件的新用户。
Poxviruses taking a ride on actin: new users of known hardware.
机构信息
Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Inhoffen Strasse 7, 38124 Braunschweig, Germany.
出版信息
Cell Host Microbe. 2009 Dec 17;6(6):497-9. doi: 10.1016/j.chom.2009.11.010.
PMID:20006837
Abstract
Vaccinia virus uses A36 to recruit the actin polymerization effectors Nck and N-WASP to drive actin tail formation. Now, Dodding and Way identify functional orthologs of A36 in other vertebrate poxviruses that harbor varying numbers of Nck-binding sites and can substitute for A36 despite no sequence homology.
摘要
痘苗病毒利用 A36 招募肌动蛋白聚合效应物 Nck 和 N-WASP 来驱动肌动蛋白尾的形成。现在，Dodding 和 Way 在其他具有不同数量 Nck 结合位点的脊椎动物痘病毒中鉴定出 A36 的功能同源物，尽管它们没有序列同源性，但可以替代 A36。
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