Department of Bioimaging and Radiological Sciences, Institute of Radiology, "A. Gemelli" Hospital - Catholic University, L.go A Gemelli 8, 00168 Rome, Italy.
Eur J Radiol. 2011 Jul;79(1):21-8. doi: 10.1016/j.ejrad.2009.11.016. Epub 2009 Dec 16.
To investigate the possibility of reducing radiation dose exposure while maintaining image quality using multidetector computed tomography angiography (MDCTA) with high-concentration contrast media in patients undergoing follow-up after endovascular aortic repair (EVAR) to treat abdominal aortic aneurysm.
In this prospective, single center, intra-individual study, patients underwent two consecutive MDCTA scans 6 months apart, one with a standard acquisition protocol (130 mAs/120 kV) and 120 mL of iomeprol 300, and one using a low dose protocol (100 mAs/80 kV) and 90 mL of iomeprol 400. Images acquired during the arterial phase of contrast enhancement were evaluated both qualitatively and quantitatively for image noise and intraluminal contrast enhancement.
Thirty adult patients were prospectively enrolled. Statistically significantly higher attenuation values were measured in the low-dose acquisition protocol compared to the standard protocol, from the suprarenal abdominal aorta to the common femoral artery (p<0.0001; all vascular segments). Qualitatively, image quality was judged significantly (p=0.0002) better with the standard protocol than with the low-dose protocol. However, no significant differences were found between the two protocols in terms of contrast-to-noise ratio (CNR) (13.63±6.97 vs. 11.48±8.13; p=0.1058). An overall dose reduction of up to 74% was observed for the low-dose protocol compared with the standard protocol.
In repeat follow-up examinations of patients undergoing EVAR for abdominal aortic aneurysm, a low-dose radiation exposure acquisition protocol provides substantially reduced radiation exposure while maintaining a constant CNR and good image quality.
研究在接受腹主动脉瘤血管内修复(EVAR)治疗后进行随访的患者中,使用高浓度对比剂进行多排螺旋 CT 血管造影(MDCTA)是否可以在保持图像质量的同时降低辐射剂量。
在这项前瞻性、单中心、个体内研究中,患者在 6 个月的时间间隔内进行两次连续的 MDCTA 扫描,一次使用标准采集方案(130 mAs/120 kV 和 120 mL 碘普罗胺 300),一次使用低剂量方案(100 mAs/80 kV 和 90 mL 碘普罗胺 400)。在对比增强的动脉期采集图像,对图像噪声和管腔内对比增强进行定性和定量评估。
30 名成年患者被前瞻性纳入研究。低剂量采集方案与标准方案相比,在肾动脉以上的腹主动脉至股总动脉的测量值中,均有统计学显著更高的衰减值(p<0.0001;所有血管节段)。定性评估结果显示,标准方案的图像质量显著优于低剂量方案(p=0.0002)。然而,在对比噪声比(CNR)方面,两个方案之间没有显著差异(13.63±6.97 vs. 11.48±8.13;p=0.1058)。与标准方案相比,低剂量方案的总辐射剂量降低了高达 74%。
在对接受腹主动脉瘤 EVAR 治疗的患者进行重复随访检查时,低剂量辐射采集方案可在保持恒定 CNR 和良好图像质量的同时,显著降低辐射暴露。