Ashton N, Balment R J
Department of Physiological Sciences, University of Manchester, UK.
Acta Endocrinol (Copenh). 1991 Jan;124(1):91-7. doi: 10.1530/acta.0.1240091.
Renal water and electrolyte handling and related plasma hormone levels were measured in male and female New Zealand genetically hypertensive and normotensive rats, in an attempt to establish any potentially important sex-related differences in these parameters. Male hypertensive rats had higher blood pressure than female hypertensive rats, but normotensive rats showed no such sex difference. Both groups of males had higher fluid turnover rates than respective females, and this was associated with raised plasma vasopressin in hypertensive males. Female hypertensive rats excreted more sodium, potassium and chloride in association with lower plasma aldosterone and higher corticosterone levels compared with the other groups. Plasma electrolytes did not differ between the four groups, but plasma osmolality was higher in hypertensive than normotensive rats of both sexes. A higher rate of electrolyte loss and lower fluid turnover in association with reduced plasma vasopressin may contribute to the lower blood pressure of female compared with male hypertensive rats.
对雄性和雌性新西兰遗传性高血压大鼠及正常血压大鼠的肾脏水和电解质处理情况以及相关血浆激素水平进行了测量，旨在确定这些参数中任何潜在的重要性别差异。雄性高血压大鼠的血压高于雌性高血压大鼠，但正常血压大鼠未表现出这种性别差异。两组雄性大鼠的液体周转率均高于各自的雌性大鼠，且这与高血压雄性大鼠血浆血管加压素升高有关。与其他组相比，雌性高血压大鼠排泄更多的钠、钾和氯，同时血浆醛固酮水平较低，皮质酮水平较高。四组之间的血浆电解质无差异，但高血压大鼠的血浆渗透压高于两性的正常血压大鼠。与血浆血管加压素降低相关的较高电解质丢失率和较低液体周转率可能导致雌性高血压大鼠的血压低于雄性高血压大鼠。
