Department of Hepatobiliary and Pancreatosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Hepatobiliary Pancreat Dis Int. 2009 Dec;8(6):653-6.
Autoimmune pancreatitis (AIP) is a unique chronic inflammation of the pancreas in which autoimmune mechanisms are involved in the pathogenesis. It is characterized by clinical, histopathological, radiographic, serologic and therapeutic features. Since it was first described in 1995, increasing numbers of AIP patients have been diagnosed.
In this study, the data from 2 patients with AIP who had elevation of serum immunoglobulin G, positive autoantibody, swelling of the pancreas and narrowing of the main pancreatic duct on imaging were analyzed retrospectively.
With the initial diagnosis of AIP, both patients underwent regular prednisone therapy, which was initiated at a dose of 40 mg per day with a tapering schedule of 5 mg every 2 weeks. The patients responded very well to treatment with prednisone.
AIP is a relatively new disease entity. Although it is diagnosed by distinct characteristics of the clinical, radiologic, histopathologic, and serologic findings, many questions require further clarification, including its relationship to other autoimmune diseases and misdiagnosis as pancreaticobiliary malignancies.
自身免疫性胰腺炎（AIP）是一种独特的胰腺慢性炎症，其发病机制涉及自身免疫机制。它的特点是临床、组织病理学、影像学、血清学和治疗特征。自 1995 年首次描述以来，越来越多的 AIP 患者被诊断出来。
本研究回顾性分析了 2 例 AIP 患者的资料，这些患者的血清 IgG 升高、自身抗体阳性、胰腺肿胀和主胰管狭窄。
最初诊断为 AIP 后，这 2 名患者均接受了常规泼尼松治疗，起始剂量为每天 40mg，每 2 周逐渐减少 5mg。患者对泼尼松治疗反应良好。
AIP 是一种相对较新的疾病实体。尽管它是通过临床、影像学、组织病理学和血清学特征明确诊断的，但仍有许多问题需要进一步阐明，包括其与其他自身免疫性疾病的关系和误诊为胰胆管恶性肿瘤。
