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中东人群拇指多指畸形类型的分布:228例手部研究

The distribution of the types of thumb polydactyly in a Middle Eastern population: a study of 228 hands.

作者信息

Al-Qattan M M

机构信息

King Saud University, Riyadh, Saudi Arabia.

出版信息

J Hand Surg Eur Vol. 2010 Mar;35(3):182-7. doi: 10.1177/1753193409352417. Epub 2009 Dec 9.

Abstract

Several series have reported the distribution of the types of thumb polydactyly in the Caucasian and Far Eastern populations. No data are available for the Middle East. A total of 196 Saudi patients (228 hands) with thumb polydactyly were reviewed. The most common type was Wassel type IV (33.8%) and the least common was Wassel type I (0.4%). A total of 26 hands (11.4%) did not fit into the classic Wassel types including 18 cases of rudimentary duplications, two cases of thumb triplication, and five cases of thumb duplication with symphalangism. Concurrent ipsilateral little finger triplication (one case) and contralateral thumb aplasia/hypoplasia (two cases) were seen and the developmental biology of these cases are discussed. After reviewing our results and other series in the literature, we concluded that Wassel types IV and I remain to be the most and least common types respectively in almost all races. However, the genetic pools of various races greatly affect the distribution of other non-classic duplications (unclassifiable by Wassel classification) such as rudimentary duplication in the Far East, triplication in the Southwestern region of the Netherlands, and symphalangism in Asia.

摘要

已有多个系列报道了白种人和远东人群中拇指多指畸形类型的分布情况。中东地区尚无相关数据。我们回顾了196例沙特拇指多指畸形患者(228只手)的情况。最常见的类型是瓦塞尔IV型(33.8%),最不常见的是瓦塞尔I型(0.4%)。共有26只手(11.4%)不符合经典的瓦塞尔类型,包括18例残遗性重复、2例拇指三指畸形和5例伴有关节融合的拇指重复畸形。我们还发现了1例同侧小指三指畸形和2例对侧拇指发育不全/发育不良的情况,并对这些病例的发育生物学进行了讨论。在回顾我们的研究结果及文献中的其他系列报道后,我们得出结论,在几乎所有种族中,瓦塞尔IV型和I型仍然分别是最常见和最不常见的类型。然而,不同种族的基因库极大地影响了其他非经典重复畸形(无法用瓦塞尔分类法分类)的分布,如远东地区的残遗性重复、荷兰西南部地区的三指畸形以及亚洲地区的关节融合。

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