School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
International Vaccine Institute, Seoul, Republic of Korea.
J Med Microbiol. 2010 Mar;59(Pt 3):302-308. doi: 10.1099/jmm.0.017053-0. Epub 2009 Dec 10.
Currently, Vibrio cholerae O1 serogroup biotype El Tor strains producing classical type cholera toxin (altered strains or El Tor variants) are prevalent in Asia and in Mozambique. Mozambican strains collected in 2004 contained a tandem repeat of CTX prophage on the small chromosome and each CTX prophage harboured the classical rstR and classical ctxB. We found that the majority of the strains collected in 2005 in Mozambique contained extra elements on the large chromosome in addition to the tandem repeat of CTX prophage on the small chromosome. New type RS1 elements RS1(cla) and RS1(env), and a CTX(env) with rstR(env) and the classical ctxB were identified on the large chromosome of the Mozambican isolates collected in 2005.
目前，产生经典型霍乱毒素的霍乱弧菌 O1 血清群生物型 El Tor 菌株（已改变的菌株或 El Tor 变体）在亚洲和莫桑比克流行。2004 年在莫桑比克采集的菌株在小染色体上含有 CTX 噬菌体的串联重复，每个 CTX 噬菌体都含有经典的 rstR 和 ctxB。我们发现，2005 年在莫桑比克采集的大多数菌株除了小染色体上 CTX 噬菌体的串联重复外，在大染色体上还含有额外的元件。在 2005 年采集的莫桑比克分离株的大染色体上发现了新型 RS1 元件 RS1(cla)和 RS1(env)，以及带有 rstR(env)和经典 ctxB 的 CTX(env)。
