盘基网柄菌肌球蛋白重链激酶C的WD重复结构域在底物靶向和细胞定位中均发挥作用。
WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.
作者信息
Franklin Atiya, Hyatt Linzi, Chowdhury Alyssa, Steimle Paul A
机构信息
Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
出版信息
Eukaryot Cell. 2010 Feb;9(2):344-9. doi: 10.1128/EC.00242-09. Epub 2009 Dec 11.
Abstract
Myosin II disassembly in Dictyostelium discoideum is regulated by three structurally related myosin heavy chain kinases (myosin II heavy chain kinase A [MHCK-A], -B, and -C). We show that the WD repeat domain of MHCK-C is unique in that it mediates both substrate targeting and subcellular localization, revealing a target for regulation that is distinct from those of the other MHCKs.
摘要
盘基网柄菌中的肌球蛋白II解聚由三种结构相关的肌球蛋白重链激酶（肌球蛋白II重链激酶A [MHCK-A]、-B和-C）调节。我们发现，MHCK-C的WD重复结构域具有独特性，它既能介导底物靶向，又能介导亚细胞定位，揭示了一个与其他MHCKs不同的调节靶点。
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本文引用的文献
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Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.将Ras与肌球蛋白功能联系起来：RasGEF Q，一种盘基网柄菌属中RasB的交换因子，影响肌球蛋白II的功能。
J Cell Biol. 2008 Jun 2;181(5):747-60. doi: 10.1083/jcb.200710111. Epub 2008 May 26.
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Nonmuscle myosin II moves in new directions.非肌肉肌球蛋白II向新的方向移动。
J Cell Sci. 2008 Jan 1;121(Pt 1):11-8. doi: 10.1242/jcs.007112.
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Rap1 controls cell adhesion and cell motility through the regulation of myosin II.Rap1通过调节肌球蛋白II来控制细胞黏附和细胞运动。
J Cell Biol. 2007 Mar 26;176(7):1021-33. doi: 10.1083/jcb.200607072. Epub 2007 Mar 19.
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The regulation of myosin II in Dictyostelium.盘基网柄菌中肌球蛋白II的调控
Eur J Cell Biol. 2006 Sep;85(9-10):969-79. doi: 10.1016/j.ejcb.2006.04.004. Epub 2006 Jun 30.
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