James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Hematology Am Soc Hematol Educ Program. 2009:532-41. doi: 10.1182/asheducation-2009.1.532.
Treatment of patients with transformed lymphoma presents a significant challenge to the practicing physician. Indeed, the transformation of follicular lymphoma to a more aggressive histology is inherent to the biology of this disease and is often associated with an aggressive clinical course, resulting in a poor prognosis. Recent population-based studies have better defined the incidence of this event, and recent laboratory studies have defined the molecular and immunological processes associated with transformation. These studies will be discussed in this review, as will the treatment options for these patients.
治疗转化型淋巴瘤患者对临床医生来说是一个巨大的挑战。事实上，滤泡性淋巴瘤向侵袭性组织学的转化是这种疾病的固有生物学特性，常伴有侵袭性临床病程，导致预后不良。最近的基于人群的研究更好地定义了这种事件的发生率，最近的实验室研究也定义了与转化相关的分子和免疫学过程。本综述将讨论这些研究，以及这些患者的治疗选择。
