Department of Medicine, Rheumatology Division, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Lupus. 2010 Mar;19(3):262-7. doi: 10.1177/0961203309351728. Epub 2009 Dec 14.
Nickel intolerance owing to sensitization is a growing problem. The main objective of this study was to examine the relationship between nickel chloride and induction of autoimmunity in genetically susceptible rats. Thirty brown Norway rats were randomized into four treatment groups; the first and second groups received nickel chloride 4.5 mg in 0.2 ml normal saline either orally or subcutaneously, and the third and fourth groups (controls) received normal saline (0.9%) 0.2 ml through the same routes. A significant number of rats (P < 0.05) that received nickel chloride by the subcutaneous or oral routes showed a high level of serum antinuclear antibody (ANA) compared with controls. A significant number of rats (P < 0.05) that received nickel chloride by the subcutaneous route showed high serum anti-SSA, but the number of rats with anti-SSA was insignificant in the group that received nickel by the oral route. Other autoantibodies found in both groups (anti-double-stranded (ds)DNA, anti-Smith, anti-SSB) showed a gradual increase, but the number of rats with positive titers post exposure was not significant statistically. Nickel chloride exposure in the rats appeared to induce the development of autoimmunity. A longer duration following exposure to nickel chloride seems to be associated with greater risks.
镍不耐受由于致敏是一个日益严重的问题。本研究的主要目的是探讨氯化镍和诱导自身免疫遗传易感性大鼠之间的关系。30 只褐鼠随机分为四组治疗;第一和第二组分别接受镍氯 4.5 毫克在 0.2 毫升生理盐水口服或皮下，和第三和第四组（对照组）接受生理盐水（0.9%）通过相同的路线 0.2 毫升。大量的大鼠（P < 0.05），接受镍氯通过皮下或口服途径表现出高水平的血清抗核抗体（ANA）比对照组。大量的大鼠（P < 0.05），接受镍氯通过皮下途径显示高血清抗 SSA，但大鼠的数量与抗 SSA 是微不足道的组，接受镍通过口服途径。其他自身抗体在两组（抗双链（ds）DNA，抗史密斯，抗 SSB）发现逐渐增加，但大鼠阳性率并没有显著增加后接触统计学意义。镍氯暴露在大鼠似乎诱导自身免疫的发展。较长时间的暴露于镍氯似乎与更大的风险相关。
