College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, China.
Plant Signal Behav. 2009 Nov;4(11):1007-9. doi: 10.4161/psb.4.11.9717. Epub 2009 Nov 3.
Jasmonates and related compounds have been highlighted recently in the field of plant physiology and plant molecular biology due to their significant regulatory roles in the signaling pathway for the diverse aspects of plant development and survival. Though a considerable amount of studies concerning their biological effects in different plants have been widely reported, the molecular details of the signaling mechanism are still poorly understood. This review sheds new light on the structural requirements for the bioactivity/property of jasmonic acid derivatives in current computational perspective, which differs from previous research that mainly focus on their biological evaluation, gene and metabolic regulation and the enzymes in their biosynthesis. The computational results may contribute to further understanding the mechanism of drug-receptor interactions in their signaling pathway and designing novel plant growth regulators as high effective ecological pesticides.
茉莉酸及其相关化合物由于在植物发育和生存的各个方面的信号通路中具有重要的调节作用，最近在植物生理学和植物分子生物学领域受到了关注。虽然已经广泛报道了关于它们在不同植物中的生物学效应的大量研究，但信号机制的分子细节仍知之甚少。本综述从当前计算角度探讨了茉莉酸衍生物生物活性/性质的结构要求，这与以前主要关注其生物评价、基因和代谢调控以及生物合成中酶的研究不同。计算结果可能有助于进一步了解其信号通路中药物-受体相互作用的机制，并设计新型高效生态农药作为植物生长调节剂。
