多方法评估围生期感染 HIV-1 的儿童的服药依从性：预测生物标志物的不规律服药的影响。

Multimethod adherence assessment in children with perinatally acquired HIV-1: the influence of off-schedule dosing in predicting biological markers.

机构信息

Department of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

出版信息

Pediatr Infect Dis J. 2010 Apr;29(4):372-4. doi: 10.1097/INF.0b013e3181c67686.

PMID:20009786

Abstract

To improve upon adherence assessment in children with HIV, multimethod adherence strategies (pill count, missed doses, off-schedule dosing) were conducted concurrent with viral load and CD4% biomarker assays. Off-schedule dosing predicted both health status markers, while the more common strategies did not. Findings support inclusion of off-schedule dosing concurrent with collection of biomarkers to assess adherence in children with HIV.

摘要

为了提高对 HIV 感染儿童的服药依从性评估，采用了多种方法（药物计数、漏服剂量、不按时服药）进行依从性评估，同时进行病毒载量和 CD4%生物标志物检测。不按时服药预测了这两个健康状况标志物，而更常见的方法则没有。研究结果支持在采集生物标志物的同时纳入不按时服药来评估 HIV 感染儿童的服药依从性。