Novak Gabriela, Gallo Alexandra, Zai Clement C, Meltzer Herbert Y, Lieberman Jeffrey A, Potkin Steven G, Voineskos Aristotle N, Remington Gary, Kennedy James L, Levesque Daniel, Le Foll Bernard
Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Psychiatr Genet. 2010 Feb;20(1):39-43. doi: 10.1097/YPG.0b013e3283351221.
Recent evidence has identified the NR4A1 (NUR77, NGFI-B) gene as a strong candidate for involvement in tardive dyskinesia (TD). We have investigated the association of six single nucleotide polymorphisms within the NR4A family of genes with TD in a sample of 171 patients with schizophrenia of Caucasian descent. The NR4A1 single nucleotide polymorphism (SNP) marker rs2603751 showed a nominal association with the risk of TD, as well as with the extent of TD based on the Abnormal Involuntary Movements Scale (AIMS) scores. The haplotype generated by the markers rs2603751 and rs2701124 also showed association with TD and, after adjustment for multiple testing, both the NR4A1 marker rs2603751 and the haplotype continued to show a trend toward association with TD. Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD.
近期证据表明，NR4A1（NUR77，NGFI-B）基因是迟发性运动障碍（TD）的一个有力候选相关基因。我们在171名高加索裔精神分裂症患者样本中，研究了NR4A基因家族内六个单核苷酸多态性与TD的关联。NR4A1单核苷酸多态性（SNP）标记rs2603751显示出与TD风险以及基于异常不自主运动量表（AIMS）评分的TD严重程度存在名义上的关联。由标记rs2603751和rs2701124生成的单倍型也显示出与TD有关联，在进行多重检验校正后，NR4A1标记rs2603751和单倍型均继续呈现出与TD相关的趋势。尽管本研究结果受样本量小的限制，但它提供了重要的初步数据，值得进一步研究NR4A1变异在TD中的作用。
Zotero 插件