Department of Clinical and Experimental Medicine, Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy.
Minerva Med. 2009 Dec;100(6):467-78.
Respiratory viral infections are recognized as the most frequent cause of asthma and chronic obstructive pulmonary disease (COPD) exacerbations with rhinovirus (i.e. the virus of the common cold) being the most frequent identified virus. The recent development of human experimental models of rhinovirus-induced asthma and COPD exacerbations represent innovative tools with the potential to increase our understanding in this field. Moreover this models will provide the opportunity to test, in a carefully controlled setting, novel pharmacological compounds. In this review we will provide an overview of the role of viral infections in asthma and COPD exacerbations and in particular we will summarize the inflammatory and immunological mechanisms that can pave the way to exacerbation following respiratory viral infection in these patients.
呼吸道病毒感染被认为是哮喘和慢性阻塞性肺疾病（COPD）加重的最常见原因，其中鼻病毒（即普通感冒病毒）是最常见的病毒。最近开发的人类鼻病毒诱导的哮喘和 COPD 加重的实验模型是具有创新性的工具，有可能增加我们在这一领域的认识。此外，这些模型将提供机会，在精心控制的环境下，测试新型的药物化合物。在这篇综述中，我们将概述病毒感染在哮喘和 COPD 加重中的作用，特别是总结炎症和免疫机制，这些机制为这些患者在呼吸道病毒感染后发生加重铺平了道路。
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