黑色素瘤分子亚型：统一与矛盾的结果。
Melanoma molecular subtypes: unifying and paradoxical results.
机构信息
Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
出版信息
J Invest Dermatol. 2010 Jan;130(1):12-4. doi: 10.1038/jid.2009.332.
Abstract
In this issue, Hacker and colleagues provide further evidence that molecular subtypes of malignant melanoma may develop along divergent pathways. The authors did not find an association between somatic BRAF-mutant melanoma and germline melanocortin-1 receptor (MC1R) gene status. We discuss this seeming paradox in light of previous studies demonstrating strong associations.
摘要
在本期中，Hacker 及其同事提供了进一步的证据，表明恶性黑色素瘤的分子亚型可能沿着不同的途径发展。作者没有发现体细胞 BRAF 突变型黑色素瘤与种系黑素皮质素 1 受体 (MC1R) 基因状态之间存在关联。我们根据先前的研究结果，对这一看似矛盾的现象进行了讨论，这些研究结果表明存在强烈的相关性。
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Red hair is the null phenotype of MC1R.红发是 MC1R 的无效表型。
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MC1R variants increase risk of melanomas harboring BRAF mutations.黑素皮质素1受体（MC1R）变体增加了携带BRAF突变的黑色素瘤的风险。
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