水溶性可生物共轭反式AB-卟啉的设计与合成。
Design and synthesis of water-soluble bioconjugatable trans-AB-porphyrins.
作者信息
Muresan Ana Z, Lindsey Jonathan S
机构信息
Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA.
出版信息
Tetrahedron. 2008 Dec 8;64(50):11440-11448. doi: 10.1016/j.tet.2008.08.096.
Abstract
Three free base porphyrins have been prepared that bear a polar and facially encumbering 2,4,6-tris(carboxymethoxy)phenyl motif at one meso (5-) position. The only other substituent (15-position) comprises phenyl, formyl, or p-aminophenyl. The porphyrins exhibit solubility in water (or aqueous buffer solutions) at pH >/=7 and concentrations >1 mM at room temperature. The concise syntheses, water-solubility, and bioconjugatable handle make these porphyrin constructs suitable for biological applications.
摘要
已经制备了三种游离碱卟啉，它们在一个中位（5-）位置带有一个极性且空间位阻较大的2,4,6-三（羧基甲氧基）苯基基团。唯一的其他取代基（15-位）包括苯基、甲酰基或对氨基苯基。这些卟啉在室温下pH≥7且浓度>1 mM时可溶于水（或水性缓冲溶液）。简洁的合成方法、水溶性和可生物共轭的基团使这些卟啉构建体适用于生物应用。
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