Namiki Shigehiro, Haupt S Shuichi, Kazawa Tomoki, Takashima Akira, Ikeno Hidetoshi, Kanzaki Ryohei
Research Center for Advanced Science and Technology, The University of Tokyo Tokyo, Japan.
Front Neurosci. 2009 Sep 15;3(2):206-13. doi: 10.3389/neuro.01.028.2009. eCollection 2009 Sep.
The reconstruction of large-scale nervous systems represents a major scientific and engineering challenge in current neuroscience research that needs to be resolved in order to understand the emergent properties of such systems. We focus on insect nervous systems because they represent a good compromise between architectural simplicity and the ability to generate a rich behavioral repertoire. In insects, several sensory maps have been reconstructed so far. We provide an overview over this work including our reconstruction of population activity in the primary olfactory network, the antennal lobe. Our reconstruction approach, that also provides functional connectivity data, will be refined and extended to allow the building of larger scale neural circuits up to entire insect brains, from sensory input to motor output.
大规模神经系统的重建是当前神经科学研究中的一项重大科学和工程挑战,为了理解此类系统的涌现特性,这一挑战亟待解决。我们专注于昆虫神经系统,因为它们在结构简单性和产生丰富行为库的能力之间达成了良好的平衡。迄今为止,在昆虫中已经重建了几个感觉图谱。我们将概述这项工作,包括我们对初级嗅觉网络即触角叶中群体活动的重建。我们的重建方法还能提供功能连接数据,该方法将得到改进和扩展,以构建更大规模的神经回路,直至整个昆虫大脑,涵盖从感觉输入到运动输出的全过程。