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[一家乡村医院遵循临床指南对成人社区获得性肺炎的管理]

[Management of community acquired pneumonia in adults following clinical guidelines at a rural hospital].

作者信息

Sanhueza A Luis Manuel, Vásquez P Cristián, Sepúlveda Z Fabiola, Barahona C Francisca, González C Rubén, Saldías P Fernando

机构信息

Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

Rev Med Chil. 2009 Oct;137(10):1283-90.

Abstract

BACKGROUND

A National Consensus Guideline published in 2005 established the basis for the diagnostic, severity assessment and treatment of community acquired pneumonia (CAP) in the adult population. The compliance with pneumonia clinical guidelines has been associated to a reduction in hospital stay healthcare-related costs, morbidity and mortality.

AIM

To describe the management and outcome of non-severe CAP in hospitalized adult patients treated in a rural hospital, based on the national clinical guidelines.

PATIENTS AND METHODS

Ninety six patients aged 74 +/- 13 years (50 males) hospitalized with non-severe pneumonia (group 3) at a community-based primary care center between January 1, 2006, and March 31, 2007, were evaluated.

RESULTS

Eighty percent of patients had concomitant diseases such as hypertension in 49%, diabetes in 23% and chronic obstructive pulmonary disease in 18%. All were treated with a third generation cephalosporin (ceftriaxone 1-2 g/day TV) as empirical therapy. Only 9% of patients also received a macrolide. Early switch to oral antimicrobial therapy was successful in two third of cases. Mean hospital length of stay was 5.0 +/- 2.5 days, and 30-day mortality was 6.3%.

CONCLUSIONS

Following the recommendations of the national clinical guidelines, most of these patients had a favorable response to monotherapy with a beta-lactam antimicrobial. Early switch therapy to oral antibiotic was effective and safe, reducing significantly hospital length of stay as compared to previous national clinical studies.

摘要

背景

2005年发布的一项全国性共识指南为成人社区获得性肺炎(CAP)的诊断、严重程度评估和治疗奠定了基础。遵循肺炎临床指南与缩短住院时间、降低医疗相关成本、发病率和死亡率相关。

目的

基于国家临床指南,描述在一家乡村医院接受治疗的住院成年非重症CAP患者的管理和结局。

患者与方法

对2006年1月1日至2007年3月31日期间在一家社区基层医疗中心因非重症肺炎住院的96例年龄为74±13岁(50例男性)的患者进行了评估。

结果

80%的患者患有合并症,如49%患有高血压,23%患有糖尿病,18%患有慢性阻塞性肺疾病。所有患者均接受第三代头孢菌素(头孢曲松1 - 2 g/天静脉滴注)作为经验性治疗。只有9%的患者还接受了大环内酯类药物治疗。三分之二的病例成功早期转换为口服抗菌治疗。平均住院时间为5.0±2.5天,30天死亡率为6.3%。

结论

遵循国家临床指南的建议,这些患者中的大多数对β-内酰胺类抗菌药物单药治疗反应良好。早期转换为口服抗生素治疗有效且安全,与之前的国家临床研究相比,显著缩短了住院时间。

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